Evidence map›Paper›PMID 27437434›Full record

ArticleData in brief2016

Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors.

Vassilis L Tzounakas, Anastasios G Kriebardis, Hara T Georgatzakou, Leontini E Foudoulaki-Paparizos, Monika Dzieciatkowska, Matthew J Wither, Travis Nemkov, Kirk C Hansen, Issidora S Papassideri, Angelo D'Alessandro and 1 more

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. High-Throughput Metabolomics in Transfusion Medicine.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. It's in your blood: The impact of age, sex, genetic factors and exposures on stored red blood cell metabolism.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2024
    Review
  5. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  6. Review
  7. Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Impact of G6PD status on red cell storage and transfusion outcomes.Blood transfusion = Trasfusione del sangue · 2019
    Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Vassilis L TzounakasDepartment of Biology, Section of Cell Biology and Biophysics, School of Science, NKUA, Athens 15784, Greece.
Anastasios G KriebardisLaboratory of Hematology and Transfusion Medicine, Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological and Educational Institute of Athens, Athens 12210, Greece.
Hara T GeorgatzakouDepartment of Biology, Section of Cell Biology and Biophysics, School of Science, NKUA, Athens 15784, Greece.
Leontini E Foudoulaki-PaparizosRegional Blood Transfusion Center, "Agios Panteleimon" General Hospital of Nikea, Piraeus 18454, Greece.
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, 80045 CO, USA.
Matthew J WitherDepartment of Biochemistry and Molecular Genetics, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, 80045 CO, USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, 80045 CO, USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, 80045 CO, USA.
Issidora S PapassideriDepartment of Biology, Section of Cell Biology and Biophysics, School of Science, NKUA, Athens 15784, Greece.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado, School of Medicine-Anschutz Medical Campus, Aurora, 80045 CO, USA.
Marianna H AntonelouDepartment of Biology, Section of Cell Biology and Biophysics, School of Science, NKUA, Athens 15784, Greece.
University of Colorado Anschutz Medical Campus · USGeneral Hospital of Nikea · GRTechnological Educational Institute of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article contains data on the variation in several physiological parameters of red blood cells (RBCs) donated by eligible glucose-6-phosphate dehydrogenase (G6PD) deficient donors during storage in standard blood bank conditions compared to control, G6PD sufficient (G6PD(+)) cells. Intracellular reactive oxygen species (ROS) generation, cell fragility and membrane exovesiculation were measured in RBCs throughout the storage period, with or without stimulation by oxidants, supplementation of N-acetylcysteine and energy depletion, following incubation of stored cells for 24 h at 37 °C. Apart from cell characteristics, the total or uric acid-dependent antioxidant capacity of the supernatant in addition to extracellular potassium concentration was determined in RBC units. Finally, procoagulant activity and protein carbonylation levels were measured in the microparticles population. Further information can be found in "Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells" [1].

Indexed as

AnnV, annexin VCell fragilityCPD, citrate-phosphate-dextroseFRAP, ferric reducing antioxidant powerFSC, forward scatterG6PD deficiencyG6PD−, G6PD deficiencyG6PD, glucose-6-phosphate dehydrogenaseHb, hemoglobinHct, hematocritK+, potassiumMCF, mean corpuscular fragilityMFI, mechanical fragility indexMicroparticlesMP, micoparticles, microvesiclesMPPA, microparticles pro-coagulant activityNAC, N-acetylcysteineNS, non-storedOxidative stressPBS, phosphate buffer salinePCI, protein carbonylation indexPS, phosphatidylserineRBC, red blood cellRed blood cell storage lesionRFU, relative fluorescence unitsROS, reactive oxygen speciesSAGM, saline-adenine-glucose-mannitolSSC, side scatterTAC, total antioxidant capacitytBHP, tert-Butyl hydroperoxideUA-dep AC, uric acid dependent antioxidant capacityUA-ind AC, uric acid independent antioxidant capacity

Identifiers

PMID27437434
PMCPMC4939423
OpenAlexW2473487093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.