ArticleJournal of clinical and diagnostic research : JCDR2016
The Mouthwash War - Chlorhexidine vs. Herbal Mouth Rinses: A Meta-Analysis.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Aloe Vera Mouthwashes on Plaque and Gingivitis Indices in Children (Clinical Randomized Controlled Trial)
Antibacterial, Antiplaque and Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness of herbal oral care products in reducing dental plaque and gingivitis: an overview of systematic reviews.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2024Pooled it
- Preprocedural mouth rinses for preventing transmission of infectious diseases through aerosols in dental healthcare providers.The Cochrane database of systematic reviews · 2022Pooled it
- Effects of Chlorine Dioxide on Oral Hygiene - A Systematic Review and Meta-analysis.Current pharmaceutical design · 2020Pooled it
- Efficacy of chlorhexidine rinses after periodontal or implant surgery: a systematic review.Clinical oral investigations · 2019Pooled it
- Effect of Mouthwashes on the Mechanical Properties and Color Stability of Composite Material.Materials (Basel, Switzerland) · 2026Article
- Assessment of the Efficacy ofInternational journal of clinical pediatric dentistry · 2025Article
- Preliminary cytotoxicity assessment of Jaftex vs. chlorhexidine mouthwashes on human gingival fibroblasts and oral squamous cell carcinoma.BMC oral health · 2025Article
- Who are the patients who use non-pharmacological home remedies? Cross-sectional study in Switzerland and France.Family practice · 2024Article
- Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention.Current issues in molecular biology · 2024Review
- Herbal Mouthrinses for Prevention of Dental Caries in Children and Adolescents: A Systematic Review.International journal of clinical pediatric dentistry · 2024Article
- The Role of Natural Compounds in Optimizing Contemporary Dental Treatment-Current Status and Future Trends.Journal of functional biomaterials · 2023Review
- Investigation of the Antibacterial, Anti-Biofilm, and Antioxidative Effect ofMicroorganisms · 2022Article
- Chlorhexidine residues in sludge from municipal wastewater treatment plants: analytical determination and toxicity evaluation.Analytical and bioanalytical chemistry · 2022Article
- Evidence on the Use of Mouthwash for the Control of Supragingival Biofilm and Its Potential Adverse Effects.Antibiotics (Basel, Switzerland) · 2022Review
- Cannabinoids infused mouthwash products are as effective as chlorhexidine on inhibition of total-culturable bacterial content in dental plaque samples.Journal of cannabis research · 2020Article
- Efficacy of an All-Natural Polyherbal Mouthwash in Patients With Periodontitis: A Single-Blind Randomized Controlled Trial.Frontiers in physiology · 2019Article
- Adverse events associated with home use of mouthrinses: a systematic review.Therapeutic advances in drug safety · 2019Review
- Efficacy of Ayurvedic drugs as compared to chlorhexidine in management of chronic periodontitis: A randomized controlled clinical study.Journal of Indian Society of PeriodontologyArticle
- Clinical and microbiological effects of 1%Journal of Indian Society of PeriodontologyArticle
- Comparative evaluation of the efficacy of a herbal mouthwash and chlorhexidine mouthwash on select periodontal pathogens: AnJournal of Indian Society of PeriodontologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMouthwashes are often prescribed in dentistry for prevention and treatment of several oral conditions. In the recent times the use of naturally occurring products what is otherwise known as grandmothers remedy are used on a large scale. This has now called for a newer age of mouth washes but is the new age mouth washes at par with the gold standard or even better than them this study investigates.
aimThe aim of the present study was to compare the effect of two broad categories of mouth washes namely chlorhexidine and herbal mouth washes. MATERIALS AND
methodsEleven randomized control studies were pooled in for the meta-analysis. The search was done from the Pub Med Central listed studies with the use keywords with Boolean operators (chlorhexidine, herbal, mouth wash, randomized control trials). The fixed effects model was used for analysis.
resultsThis meta-analysis brings to light, the fact that a wide range of newer herbal products are now available. As with a plethora of herbal mouthwashes available it is the need of the hour to validate their potential use and recommendation. This study found that only two studies favor the use of herbal products and four studies favor the use of chlorhexidine, of the 11 studies that were analyzed.
conclusionMore studies are required under well controlled circumstances to prove that herbal products can equate or replace the 'gold standard' chlorhexidine. Herbal products are heterogeneous in nature, their use should be advised only with more scientific proof.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.