ArticleJournal of clinical and diagnostic research : JCDR2016
Parasite and the Circulating Pool- Characterisation of Leukocyte Number and Morphology in Malaria.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Prognostic factors in malaria patients with acute kidney injury: a systematic review and meta analysis.Renal failure · 2026Pooled it
- Reduction in total leukocytes in malaria patients compared to febrile controls: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Clinical, hematobiochemical and phylogenetic studies of bubaline malaria in Indian water buffaloes (Bubalus bubalis).Tropical animal health and production · 2026Article
- Overview of the host immune response toJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Haematological abnormalities as diagnostic indicators of malaria in returning travellers: a retrospective study at Mohamed V Military Instruction Hospital.Access microbiology · 2025Article
- Article
- Clinical Progression ofPathogens (Basel, Switzerland) · 2022Article
- Clinical and Molecular Approach to Adult-Onset, Neoplastic Monocytosis.Current hematologic malignancy reports · 2021Review
- Discriminant value of automated leucocyte VCS parameters in the detection of tropical infections.Journal of clinical laboratory analysis · 2021Article
- Hematological profiles of malaria-infected patients in an endemic area of Peru.Revista peruana de medicina experimental y salud publicaArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHaematological changes are the most common complications encountered in malaria. There is significant correlation between several of the haematological parameters and the clinical profile, prognosis and mortality in malaria. White cell counts and differentials are among the most basic and primary investigations done in a patient presenting with fever of short duration.
aimThis study analyzes the numerical and morphological changes in White Blood Cells (WBCs) in peripheral blood in patients with acute malaria in endemic region in an effort to get a picture of specific changes that could be identified by basic investigations. MATERIALS AND
methodsThis study was conducted in tertiary care hospital in a region endemic for malaria. EDTA anticoagulated venous blood samples from 600 patients diagnosed with vivax and falciparum malaria was analysed in Coulter counter LH 500 for the white cell count and differentials. Morphological changes were looked for in Leishman stained peripheral blood smear. Comparison with age matched healthy controls was done by ANOVA with Bonferroni test wherever applicable.
resultsPatients with malaria showed significant leucopenia, neutrophilia, lymphocytopenia, monocytosis and eosinopenia. Lymphocytopenia was more severe in the falciparum group as compared to the vivax group. A higher White Cell Count (WCC) was seen in patients with higher haemoglobin levels in vivax group. The total leukocyte count showed a negative correlation with neutrophil count in falciparum malaria and a strong positive correlation with neutrophil count in vivax malaria. Band neutrophils were seen in 10% of the patients with falciparum and 1.1% of patients with vivax malaria. Atypical plasmacytoid lymphocytes were the only notable morphological finding.
conclusionChanges in leukocyte number and morphology in the peripheral blood are common. A combination of monocytosis and eosinopenia in a patient presenting with fever should alert the observer to the presence of malaria and should prompt a repeat blood smear examination in case of initial negative results for the parasite.
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