Evidence map›Paper›PMID 27437145›Full record

ArticleActa naturae

Inhibition of Poly(ADP-Ribose) Polymerase by Nucleic Acid Metabolite 7-Methylguanine.

D K Nilov, V I Tararov, A V Kulikov, A L Zakharenko, I V Gushchina, S N Mikhailov, O I Lavrik, V K Švedas

Open access · hybridAbstract read
PubMed Full text at PMC
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine.International journal of molecular sciences · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

D K NilovLomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Leninskie Gory 1, bldg. 40, Moscow, 119991, Russia ; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Leninskie Gory 1, bldg. 73, Moscow, 119991, Russia.
V I TararovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 119991 , Russia.
A V KulikovLomonosov Moscow State University, Faculty of Fundamental Medicine, Lomonosovsky avenue 31 -5, Moscow, 119192, Russia.
A L ZakharenkoInstitute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Lavrentiev avenue 8, Novosibirsk, 630090, Russia.
I V GushchinaLomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Leninskie Gory 1, bldg. 73, Moscow, 119991, Russia.
S N MikhailovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 119991 , Russia.
O I LavrikInstitute of Chemical Biology and Fundamental Medicine, Russian Academy of Sciences, Siberian Branch, Lavrentiev avenue 8, Novosibirsk, 630090, Russia.
V K ŠvedasLomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Leninskie Gory 1, bldg. 40, Moscow, 119991, Russia ; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Leninskie Gory 1, bldg. 73, Moscow, 119991, Russia.
Engelhardt Institute of Molecular Biology · RUInstitute of Chemical Biology and Fundamental Medicine · RULomonosov Moscow State University · RUMoscow State University · TJ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability of 7-methylguanine, a nucleic acid metabolite, to inhibit poly(ADP-ribose)polymerase-1 (PARP-1) and poly(ADP-ribose)polymerase-2 (PARP-2) has been identified in silico and studied experimentally. The amino group at position 2 and the methyl group at position 7 were shown to be important substituents for the efficient binding of purine derivatives to PARPs. The activity of both tested enzymes, PARP-1 and PARP-2, was suppressed by 7-methylguanine with IC50 values of 150 and 50 μM, respectively. At the PARP inhibitory concentration, 7-methylguanine itself was not cytotoxic, but it was able to accelerate apoptotic death of BRCA1-deficient breast cancer cells induced by cisplatin and doxorubicin, the widely used DNA-damaging chemotherapeutic agents. 7-Methylguanine possesses attractive predictable pharmacokinetics and an adverse-effect profile and may be considered as a new additive to chemotherapeutic treatment.

Indexed as

dockingmolecular modelingPARP inhibitors

Identifiers

PMID27437145
PMCPMC4947994
OpenAlexW2411790425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.