ArticleToxicological research2016
Cytotoxicity Evaluation of Essential Oil and its Component from Zingiber officinale Roscoe.
Article in Toxicological research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Antifungal activity of fresh ginger (Zingiber officinale) essential oil from ginger production waste against banana anthracnose caused by Colletotrichum musae: in vitro and in vivo evaluation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Design and Evaluation of aPharmaceutics · 2025Article
- Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies.Polymers · 2024Review
- Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects.Antioxidants (Basel, Switzerland) · 2023Review
- A Polyherbal Ashwagandha Formulation Exhibits Adjunctive Antitumor Efficacy Against U266 Myeloma Cells by Multi-Strategic Cytotoxic Effects: An Experimental Approach.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
- Essential Oil and Non-Volatile Metabolites fromPlants (Basel, Switzerland) · 2022Article
- Phytochemical Constituents and Antiproliferative Activities of Essential Oils from Four Varieties of MalaysianPlants (Basel, Switzerland) · 2022Article
- Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention.BioMed research international · 2022Review
- Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria.Heliyon · 2020Article
- Gingers and Their Purified Components as Cancer Chemopreventative Agents.Molecules (Basel, Switzerland) · 2019Review
- Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis onMolecules (Basel, Switzerland) · 2019Article
- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways.Biomolecules & therapeutics · 2019Article
- Effects of β-caryophyllene and Murraya paniculata essential oil in the murine hepatoma cells and in the bacteria and fungi 24-h time-kill curve studies.Pharmaceutical biology · 2017Article
- Terpenes from Forests and Human Health.Toxicological research · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zingiber officinale Roscoe has been widely used as a folk medicine to treat various diseases, including cancer. This study aims to re-examine the therapeutic potential of co-administration of natural products and cancer chemotherapeutics. Candidate material for this project, α-zingiberene, was extracted from Zingiber officinale Roscoe, and α-zingiberene makes up 35.02 ± 0.30% of its total essential oil. α-Zingiberene showed low IC50 values, 60.6 ± 3.6, 46.2 ± 0.6, 172.0 ± 6.6, 80.3 ± 6.6 (μg/mL) in HeLa, SiHa, MCF-7 and HL-60 cells each. These values are a little bit higher than IC50 values of general essential oil in those cells. The treatment of α-zingiberene produced nucleosomal DNA fragmentation in SiHa cells, and the percentage of sub-diploid cells increased in a concentration-dependent manner in SiHa cells, hallmark features of apoptosis. Mitochondrial cytochrome c activation and an in vitro caspase-3 activity assay demonstrated that the activation of caspases accompanies the apoptotic effect of α-zingiberene, which mediates cell death. These results suggest that the apoptotic effect of α-zingiberene on SiHa cells may converge caspase-3 activation through the release of mitochondrial cytochrome c into cytoplasm. It is considered that anti-proliferative effect of α-zingiberene is a result of apoptotic effects, and α-zingiberene is worth furthermore study to develop it as cancer chemotherapeutics.
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