Evidence map›Paper›PMID 27437029›Full record

ReviewWorld journal of emergency surgery : WJES2016

WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis.

Salomone Di Saverio, Arianna Birindelli, Micheal D Kelly, Fausto Catena, Dieter G Weber, Massimo Sartelli, Michael Sugrue, Mark De Moya, Carlos Augusto Gomes, Aneel Bhangu and 36 more

6 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of emergency surgery : WJES, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 165 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 17 pooled it
51.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03080103 completednot on this mapstarted 2017, after this paper: background citation

A Prospective Non-randomized Controlled, Multicenter, Multidisciplinary Trial Comparing Appendectomy and Conservative Treatment for Patients With Uncomplicated Acute Appendicitis (the ACTUAA STUDY).

TypeobservationalSponsorMauro PoddaRan2017 to 2019Enrolled300ConditionsAcute Appendicitis, Appendicitis Recurrent, Appendectomy, Antibiotic TherapyArmsLaparoscopic or Open appendectomy, Antibiotic-first therapy
NCT04030741 phase2 / phase3completednot on this mapstarted 2018, after this paper: background citation

Non Operative Treatment With Antibiotics Vs Surgery for Acute Non Perforated Appendicitis in Children: A Randomized Controlled Trial.

TypeinterventionalSponsorKing Edward Medical UniversityRan2018 to 2020Enrolled180ConditionsAcute AppendicitisArmsMeronem and flagyl, Appendectomy
NCT04464382 naunknown statusnot on this mapstarted 2019, after this paper: background citation

A Randomized Double-blind Clinical Trial to Evaluate the Safety and Efficacy of a Outpatient Appendectomy (PENDI_CSI)

TypeinterventionalSponsorFundación Pública Andaluza para la gestión de la Investigación en SevillaRan2019 to 2021Enrolled291ConditionsAppendicitis Acute, AppendectomyArmsOutpatient (OA), Hospitalization appendectomy (HA)
NCT04477824 completednot on this map

Is Acute Appendicitis Still a Clinical Diagnosis? Use of Preoperative Diagnostic Imaging Before Appendectomy in Denmark During 2000-15.

TypeobservationalSponsorClaus Anders Bertelsen, PhD, MDRan2000 to 2016Enrolled82,000ConditionsAppendicitisArmsDiagnostic imaging
NCT06000020 completednot on this mapstarted 2017, after this paper: background citation

Leave or Laparoscopic Appendectomy With Normal Findings - a Regional Cohort Study

TypeobservationalSponsorNordsjaellands HospitalRan2017 to 2025Enrolled1,435ConditionsAppendicitis AcuteArmsLaparoscopic appendectomy
NCT07563933 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

One Versus Five Days of Antibiotics After Appendectomy for Straightforward Acute Appendicitis: Study Protocol for a Randomized Controlled Trial

TypeinterventionalSponsorMinistry of Health and Population, EgyptRan2026 to 2027Enrolled200ConditionsPost Operative Antibiotic Therapy of Acute AppendicitisArmsa single day (24 hours) post operative
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 17 syntheses or guidelines pooled it, 437 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Stump appendicitis in children: a systematic review.Pediatric surgery international · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Acute Appendicitis in Childhood and Adulthood.Deutsches Arzteblatt international · 2020
    Pooled it
  9. Guideline
  10. Computed tomography for diagnosis of acute appendicitis in adults.The Cochrane database of systematic reviews · 2019
    Pooled it
  11. Pooled it
  12. The use of polymeric clips in securing the appendiceal stump during laparoscopic appendicectomy: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019
    Pooled it
  13. Pooled it
  14. Pooled it
  15. Effect of Delay to Operation on Outcomes in Patients with Acute Appendicitis: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
    Pooled it
  16. Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 12 countries.

Salomone Di SaverioEmergency and Trauma Surgery - Maggiore Hospital, AUSL, Bologna, Italy.ORCID 0000-0001-5685-5022
Arianna BirindelliS. Orsola Malpighi University Hospital - University of Bologna, Bologna, Italy.
Micheal D KellyLocum Surgeon, Acute Surgical Unit, Canberra Hospital, Canberra, ACT Australia.
Fausto CatenaEmergency and Trauma Surgery Department, Maggiore Hospital of Parma, Parma, Italy.
Dieter G WeberTrauma and General Surgeon Royal Perth Hospital & The University of Western Australia, Perth, Australia.
Massimo SartelliMacerata Hospital, Macerata, Italy.
Michael SugrueLetterkenny Hospital, Donegal, Ireland.
Mark De MoyaHarvard Medical School - Massachusetts General Hospital, Boston, USA.
Carlos Augusto GomesDepartment of Surgery Hospital Universitario, Universidade General de Juiz de Fora, Juiz de Fora, Brazil.
Aneel BhanguAcademic Department of Surgery, University Hospitals Birmingham NHS Foundation Trust, Edgabaston, Birmingham, UK.
Ferdinando AgrestaGeneral Surgery, Civil Hospital - ULSS19, Veneto, Adria, RO Italy.
Ernest E MooreDenver Health System - Denver Health Medical Center, Denver, USA.
Kjetil SoreideDepartment of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.
Ewen GriffithsUniversity Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital, Birmingham, UK.
Steve De CastroDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
Jeffry KashukDepartment of Surgery, University of Jerusalem, Jerusalem, Israel.
Yoram KlugerDivision of General Surgery, Rambam Health Care Campus, Haifa, Israel.
Ari LeppaniemiAbdominal Center, University of Helsinki, Helsinki, Finland.
Luca AnsaloniGeneral Surgery I, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Manne AnderssonDepartment of Surgery, Linkoping University, Linkoping, Sweden.
Federico CoccoliniGeneral Surgery I, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Raul CoimbraUCSD Health System - Hillcrest Campus Department of Surgery Chief Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, San Diego, CA USA.
Kurinchi S GurusamyRoyal Free Campus, University College London, London, UK.
Fabio Cesare CampanileDepartment of Surgery, San Giovanni Decollato Andosilla Hospital, Viterbo, Italy.
Walter BifflQueen's Medical Center, University of Hawaii, Honolulu, HI USA.
Osvaldo ChiaraNiguarda Hospital, Milan, Italy.
Fred MooreUniversity of Florida, Gainesville, USA.
Andrew B PeitzmanDepartment of Surgery, University of Pittsburgh School of Medicine, UPMC-Presbyterian, Pittsburgh, USA.
Gustavo P FragaFaculdade de Ciências Médicas (FCM) - Unicamp, Campinas, SP Brazil.
David CostaAlicante, Spain.
Ronald V MaierDepartment of Surgery, University of Washington, Harborview Medical Center, Seattle, WA USA.
Sandro RizoliSt. Michael Hospital, Toronto, Canada.
Zsolt J BaloghDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW Australia.
Cino BendinelliDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW Australia.
Roberto CirocchiDepartment of Surgery, Terni Hospital, University of Perugia, Terni, Italy.
Valeria ToniniS. Orsola Malpighi University Hospital - University of Bologna, Bologna, Italy.
Alice PiccininiTrauma Surgery Unit - Maggiore Hospital AUSL, Bologna, Italy.
Gregorio TugnoliTrauma Surgery Unit - Maggiore Hospital AUSL, Bologna, Italy.
Elio JovineDepartment of Surgery, Maggiore Hospital AUSL, Bologna, Italy.
Roberto PersianiCatholic University, A. Gemelli University Hospital, Rome, Italy.
Antonio BiondiDepartment of Surgery, University of Catania, Catania, Italy.
Thomas ScaleaR. Adams Cowley Trauma Center, Baltimore, MD USA.
Philip StahelDenver Health System - Denver Health Medical Center, Denver, USA.
Rao IvaturyProfessor Emeritus Virginia Commonwealth University, Richmond, VA USA.
George VelmahosHarvard Medical School - Chief of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Boston, USA.
Roland AnderssonDepartment of Surgery, Linkoping University, Linkoping, Sweden.
Denver Health Medical Center · USHarvard University · USIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITJohn Hunter Hospital · AULinköping University · SEOspedale Papa Giovanni XXIII · ITUniversity Hospitals Birmingham NHS Foundation Trust · GBAgostino Gemelli University Polyclinic · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITCanberra Hospital · AUCTO Hospital · ITFaculdade de Ciências Médicas de Minas Gerais · BRHebrew University of Jerusalem · ILHospital Universitário - Universidade Federal de Juiz de Fora · BRLetterkenny University Hospital · IEOLVG · NLOspedale di MacerataOspedale di Parma · ITOspedale Maggiore Carlo Alberto Pizzardi · ITRambam Health Care Campus · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute appendicitis (AA) is among the most common cause of acute abdominal pain. Diagnosis of AA is challenging; a variable combination of clinical signs and symptoms has been used together with laboratory findings in several scoring systems proposed for suggesting the probability of AA and the possible subsequent management pathway. The role of imaging in the diagnosis of AA is still debated, with variable use of US, CT and MRI in different settings worldwide. Up to date, comprehensive clinical guidelines for diagnosis and management of AA have never been issued. In July 2015, during the 3rd World Congress of the WSES, held in Jerusalem (Israel), a panel of experts including an Organizational Committee and Scientific Committee and Scientific Secretariat, participated to a Consensus Conference where eight panelists presented a number of statements developed for each of the eight main questions about diagnosis and management of AA. The statements were then voted, eventually modified and finally approved by the participants to The Consensus Conference and lately by the board of co-authors. The current paper is reporting the definitive Guidelines Statements on each of the following topics: 1) Diagnostic efficiency of clinical scoring systems, 2) Role of Imaging, 3) Non-operative treatment for uncomplicated appendicitis, 4) Timing of appendectomy and in-hospital delay, 5) Surgical treatment 6) Scoring systems for intra-operative grading of appendicitis and their clinical usefulness 7) Non-surgical treatment for complicated appendicitis: abscess or phlegmon 8) Pre-operative and post-operative antibiotics.

Indexed as

Acute AppendicitisAlvarado ScoreAntibioticsAppendectomyAppendiceal abscessAppendicitis diagnosis scoreComplicated appendicitisConsensus ConferenceGuidelinesLaparoscopic appendectomyNon-operative managementPhlegmon

Identifiers

PMID27437029
PMCPMC4949879
OpenAlexW2505307410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.