ArticleJournal of clinical hypertension (Greenwich, Conn.)2017
Blood Pressure and All-Cause Mortality by Level of Cognitive Function in the Elderly: Results From a Population-Based Study in Rural Greece.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Baseline and 7-Year longitudinal trajectories of systolic blood pressure and all-cause mortality in the elderly: A large prospective cohort study in China, 2017-2023.AIMS public health · 2025Article
- Effect of blood pressure on mortality in patients with cognitive impairment: a prospective cohort study.Frontiers in cardiovascular medicine · 2023Article
- Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.International journal of environmental research and public health · 2020Article
- Association between Cognitive Impairment, Vascular Disease and All-Cause Mortality.The journal of nutrition, health & aging · 2018Article
- Blood pressure and all-cause mortality by level of cognitive function in the elderly: Results from a population-based study in rural Greece: Methodological issues.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Advanced statistical methodologies to address inherent study limitations. Author Response to Ayubi and Saeid.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate whether the effect of blood pressure (BP) on mortality differs by levels of cognitive function. The associations of brachial systolic BP, diastolic BP, mean arterial pressure (MAP), and pulse pressure with all-cause mortality were prospectively explored (follow-up 7.0±2.2 years) in 660 community-dwelling individuals (≥60 years) using adjusted Cox models, stratified by cognitive impairment (Mini-Mental State Examination [MMSE] <24). No association between brachial BP variables and mortality was shown for the total sample in quartiles analysis; however, MAP in the highest quartile, compared with the second, was associated with mortality (hazard ratio, 1.85; 95% confidence intervals, 1.09-3.12) among cognitively impaired individuals. The fractional-polynomials approach for BP confirmed this finding and further showed, solely in the MMSE <24 subcohort, U-shaped trends of MAP and systolic BP, with increased mortality risk in extremely low or high values; no such pattern was evident for patients with MMSE ≥24. Elderly individuals with cognitive impairment might be more susceptible to the detrimental effects of low and elevated MAP and systolic BP.
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