Evidence map›Paper›PMID 27436494›Full record

ArticleAngiology2017

Elevated Levels of Adhesion Proteins Are Associated With Low Ankle-Brachial Index.

Cecilia Berardi, Christine L Wassel, Paul A Decker, Nicholas B Larson, Phillip S Kirsch, Mariza de Andrade, Michael Y Tsai, James S Pankow, Michele M Sale, Hugues Sicotte and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Cecilia Berardi1 Department of Internal Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Christine L Wassel3 Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester, VT, USA.
Paul A Decker2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Nicholas B Larson2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Phillip S Kirsch2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Mariza de Andrade2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Michael Y Tsai4 Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
James S Pankow5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Michele M Sale6 Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Hugues Sicotte2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Weihong Tang5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Naomi Q Hanson4 Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Mary M McDermott7 Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Michael H Criqui8 Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
Michael A Allison8 Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
Suzette J Bielinski2 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Florida · USUniversity of Minnesota · USUniversity of California, San Diego · USNorthwestern University · USUniversity of Vermont · USUniversity of Virginia · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Multi-Scale Biology of Atherosclerosis in the Cellular Adhesion PathwayR01HL098077 · NHLBI · MAYO CLINIC ROCHESTER · PI BIELINSKI, SUZETTE JANINE · 2010 to 2014
$2.8M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
LC-based Nitric Oxide Breath Monitor for Asthma ManagementR43HL095167 · NHLBI · PLATYPUS TECHNOLOGIES, LLC · PI SEN, AVIJIT · 2009 to 2010
$400k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095168 · HC · JOHNS HOPKINS UNIVERSITY · PI BLUEMKE, DAVID A. · 1999 to 2000
$375k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL098077
6 · The paper itself

Abstract

Inflammation plays a pivotal role in peripheral artery disease (PAD). Cellular adhesion proteins mediate the interaction of leukocytes with endothelial cells during inflammation. To determine the association of cellular adhesion molecules with ankle-brachial index (ABI) and ABI category (≤1.0 vs >1.0) in a diverse population, 15 adhesion proteins were measured in the Multi-Ethnic Study of Atherosclerosis (MESA). To assess multivariable associations of each protein with ABI and ABI category, linear and logistic regression was used, respectively. Among 2364 participants, 23 presented with poorly compressible arteries (ABI > 1.4) and were excluded and 261 had ABI ≤ 1.0. Adjusting for traditional risk factors, elevated levels of soluble P-selectin, hepatocyte growth factor, and secretory leukocyte protease inhibitor were associated with lower ABI ( P = .0004, .001, and .002, respectively). Per each standard deviation of protein, we found 26%, 20%, and 19% greater odds of lower ABI category ( P = .001, .01, and .02, respectively). Further investigation into the adhesion pathway may shed new light on biological mechanisms implicated in PAD.

Indexed as

Ankle Brachial IndexAgedAtherosclerosisBiomarkersCell Adhesion MoleculesEnzyme-Linked Immunosorbent AssayFemaleHumansInflammationMaleMiddle AgedPeripheral Vascular DiseasesRisk FactorsBiomarkersCell Adhesion Moleculesankle–brachial indexhepatocyte growth factorperipheral artery diseaseP-selectinsecretory leukocyte protease inhibitor

Identifiers

PMID27436494
PMCPMC5247409
OpenAlexW2490730353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.