ArticleThe Journal of infectious diseases2017
Staphylococcus aureus Infection of Human Gestational Membranes Induces Bacterial Biofilm Formation and Host Production of Cytokines.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The vaginal bacteriome of pregnant Rwandan and Kenyan women, unique regional genera associations with preterm birth.BMC microbiology · 2026Article
- Investigation of minocycline and hyaluronic acid combined with ultrasound therapy in aMicrobiology (Reading, England) · 2025Article
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.American journal of obstetrics and gynecology · 2024Review
- The Utility of Human Milk Oligosaccharides against Group BACS central science · 2023Article
- Insights into the Genital Microbiota of Women Who Experienced Fetal Death in Utero.Microorganisms · 2023Article
- Diflunisal and Analogue Pharmacophores Mediating Suppression of Virulence Phenotypes inAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health.Microbiology and molecular biology reviews : MMBR · 2022Review
- Streptococcus agalactiaemBio · 2022Article
- Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy.Nature communications · 2022Article
- Frequency and Molecular Characterization ofLife (Basel, Switzerland) · 2022Article
- The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review.Reproductive health · 2022Review
- Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus.Chembiochem : a European journal of chemical biology · 2021Article
- Perinatal Gram-Positive Bacteria Exposure Elicits Distinct Cytokine Responses In Vitro.International journal of molecular sciences · 2020Article
- Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study.Journal of perinatal medicine · 2019Article
- Raman microspectroscopy differentiates perinatal pathogens on ex vivo infected human fetal membrane tissues.Journal of biophotonics · 2019Article
- Article
- Decidual stromal cell-derived PGEAmerican journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus, a metabolically flexible gram-positive pathogen, causes infections in a variety of tissues. Recent evidence implicates S. aureus as an emerging cause of chorioamnionitis and premature rupture of membranes, which are associated with preterm birth and neonatal disease. We demonstrate here that S. aureus infects and forms biofilms on the choriodecidual surface of explanted human gestational membranes. Concomitantly, S. aureus elicits the production of proinflammatory cytokines, which could ultimately perturb maternal-fetal tolerance during pregnancy. Therefore, targeting the immunological response to S. aureus infection during pregnancy could attenuate disease among infected individuals, especially in the context of antibiotic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.