ArticleHuman brain mapping2016
Brain responses to disorder-related visual threat in panic disorder.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide.Molecular psychiatry · 2026Article
- Evidence from EEG of Abnormal Functional Connectivity and Microstates in GAD and PD.Brain topography · 2026Article
- Low-intensity transcranial focused ultrasound of the amygdala modulates neural activation during emotion processing.Frontiers in neuroimaging · 2025Article
- Article
- Enhanced interhemispheric resting-state functional connectivity of the visual network is an early treatment response of paroxetine in patients with panic disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Altered White Matter Network Topology in Panic Disorder.Journal of personalized medicine · 2023Article
- Disrupted fronto-temporal function in panic disorder: a resting-state connectome study.Brain imaging and behavior · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Neural Correlates of Transient Mal de Debarquement Syndrome: Activation of Prefrontal and Deactivation of Cerebellar Networks Correlate With Neuropsychological Assessment.Frontiers in neurology · 2020Article
- Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.Scientific reports · 2019Article
- Fear Network Model in Panic Disorder: The Past and the Future.Psychiatry investigation · 2019Article
- Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.NeuroImage. Clinical · 2019Article
- Cortical alterations in phobic postural vertigo - a multimodal imaging approach.Annals of clinical and translational neurology · 2018Article
- Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder.Journal of psychiatry & neuroscience : JPN · 2018Article
- Article
- Subclinical Agoraphobia Symptoms and Regional Brain Volumes in Non-clinical Subjects: Between Compensation and Resilience?Frontiers in psychiatry · 2018Article
- Prefrontal and amygdala engagement during emotional reactivity and regulation in generalized anxiety disorder.Journal of affective disorders · 2017Article
- Functional neuroanatomy in panic disorder: Status quo of the research.World journal of psychiatry · 2017Article
- The Neurobiology of Panic: A Chronic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Panic disorder (PD) patients show aberrant neural responses to threatening stimuli in an extended fear network, but results are only partially comparable, and studies implementing disorder-related visual scenes are lacking as stimuli. The neural responses and functional connectivity to a newly developed set of disorder-related, ecologically valid scenes as compared with matched neutral visual scenes, using event-related functional magnetic resonance imaging (fMRI) in 26 PD patients and 26 healthy controls (HC) were investigated. PD patients versus HC showed hyperactivation in an extended fear network comprising brainstem, insula, thalamus, anterior, and mid-cingulate cortex and (dorso-)medial prefrontal cortex for disorder-related versus neutral scenes. Amygdala differences between groups failed significance. Subjective levels of anxiety significantly correlated with brainstem activation in PD patients. Analysis of functional connectivity by means of beta series correlation revealed no emotion-specific alterations in connectivity in PD patients versus HC. The results suggest that subjective anxiety evoked by external stimuli is directly related to altered activation in the homeostatic alarm system in PD. With novel disorder-related stimuli, the study sheds new light on the neural underpinnings of pathological threat processing in PD. Hum Brain Mapp 37:4439-4453, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.