Evidence map›Paper›PMID 27436306›Full record

ArticleJournal of the American Heart Association2016

Comprehensive Cardiac Magnetic Resonance for Short-Term Follow-Up in Acute Myocarditis.

Julian A Luetkens, Rami Homsi, Darius Dabir, Daniel L Kuetting, Christian Marx, Jonas Doerner, Ulrike Schlesinger-Irsch, René Andrié, Alois M Sprinkart, Frederic C Schmeel and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05414162 (Multiparametric Cardiac MRI in Oncological Patients Under Chimeric Antigen Receptor T-Cell Therapy), which is not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414162 unknown statusnot on this mapstarted 2022, after this paper: background citation

Multiparametric Cardiac MRI in Oncological Patients Under Chimeric Antigen Receptor T-Cell Therapy

TypeobservationalSponsorUniversity Hospital, BonnRan2022 to 2025Enrolled60ConditionsDLBCL, Multiple Myeloma, Cytokine Release Syndrome, MyocarditisArmsCardiac MRI
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Native TJournal of magnetic resonance imaging : JMRI · 2018
    Pooled it
  4. Article
  5. Article
  6. RevisitingJournal of the American Heart Association · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multimodality Imaging in Eosinophilic Myocarditis: A Rare Cause of Heart Failure.Journal of cardiovascular development and disease · 2025
    Review
  12. Observational
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Julian A LuetkensDepartment of Radiology, University of Bonn, Germany.
Rami HomsiDepartment of Radiology, University of Bonn, Germany.
Darius DabirDepartment of Radiology, University of Bonn, Germany.
Daniel L KuettingDepartment of Radiology, University of Bonn, Germany.
Christian MarxDepartment of Radiology, University of Bonn, Germany.
Jonas DoernerDepartment of Radiology, University of Bonn, Germany.
Ulrike Schlesinger-IrschDepartment of Radiology, University of Bonn, Germany.
René AndriéDepartment of Cardiology, University of Bonn, Germany.
Alois M SprinkartDepartment of Radiology, University of Bonn, Germany.
Frederic C SchmeelDepartment of Radiology, University of Bonn, Germany.
Christian StehningPhilips Research, Hamburg, Germany.
Rolf FimmersDepartment of Medical Biometry, Informatics, and Epidemiology, University of Bonn, Germany.
Juergen GiesekeDepartment of Radiology, University of Bonn, Germany Philips Research, Hamburg, Germany.
Claas P NaehleDepartment of Radiology, University of Bonn, Germany.
Hans H SchildDepartment of Radiology, University of Bonn, Germany.
Daniel K ThomasDepartment of Radiology, University of Bonn, Germany daniel.thomas@ukb.uni-bonn.de.
University of Bonn · DEClaas (Germany) · DEPhilips (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac magnetic resonance (CMR) can detect inflammatory myocardial alterations in patients suspected of having acute myocarditis. There is limited information regarding the degree of normalization of CMR parameters during the course of the disease and the time window during which quantitative CMR should be most reasonably implemented for diagnostic work-up. METHODS AND

resultsTwenty-four patients with suspected acute myocarditis and 45 control subjects underwent CMR. Initial CMR was performed 2.6±1.9 days after admission. Myocarditis patients underwent CMR follow-up after 2.4±0.6, 5.5±1.3, and 16.2±9.9 weeks. The CMR protocol included assessment of standard Lake Louise criteria, T1 relaxation times, extracellular volume fraction, and T2 relaxation times. Group differences between myocarditis patients and control subjects were highest in the acute stage of the disease (P<0.001 for all parameters). There was a significant and consistent decrease in all inflammatory CMR parameters over the course of the disease (P<0.01 for all parameters). Myocardial T1 and T2 relaxation times-indicative of myocardial edema-were the only single parameters showing significant differences between myocarditis patients and control subjects on 5.5±1.3-week follow-up (T1: 986.5±44.4 ms versus 965.1±28.1 ms, P=0.022; T2: 55.5±3.2 ms versus 52.6±2.6 ms; P=0.001).

conclusionsIn patients with acute myocarditis, CMR markers of myocardial inflammation demonstrated a rapid and continuous decrease over several follow-up examinations. CMR diagnosis of myocarditis should therefore be attempted at an early stage of the disease. Myocardial T1 and T2 relaxation times were the only parameters of active inflammation/edema that could discriminate between myocarditis patients and control subjects even at a convalescent stage of the disease.

Indexed as

Magnetic Resonance Imaging, CineAcute DiseaseAdolescentAdultAftercareAgedCase-Control StudiesFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMyocarditisProspective StudiesYoung Adultdiagnosisfollow‐up studymagnetic resonance imagingmappingmyocarditis

Identifiers

PMID27436306
PMCPMC5015395
OpenAlexW2493867154

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.