Evidence map›Paper›PMID 27436075›Full record

ReviewThe journal of sexual medicine2016

Translational Perspective on the Role of Testosterone in Sexual Function and Dysfunction.

Carol A Podlasek, John Mulhall, Kelvin Davies, Christopher J Wingard, Johanna L Hannan, Trinity J Bivalacqua, Biljana Musicki, Mohit Khera, Nestor F González-Cadavid, Arthur L Burnett

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of sexual medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  13. The role of testosterone in male sexual function.Reviews in endocrine & metabolic disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Carol A PodlasekDepartments of Urology, Physiology, and Bioengineering, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: cap325@uic.edu.
John MulhallPediatric Endocrinology Department, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kelvin DaviesDepartment of Urology, Albert Einstein College of Medicine, New York, NY, USA.
Christopher J WingardDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
Johanna L HannanDepartments of Cell Biology, Molecular Biology and Physiology, East Carolina University, Greenville, NC, USA.
Trinity J BivalacquaJames Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Biljana MusickiJames Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Mohit KheraDepartment of Urology, Baylor College of Medicine, Houston, TX, USA.
Nestor F González-CadavidDepartment of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Arthur L BurnettJames Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USAlbert Einstein College of Medicine · USBaylor College of Medicine · USEast Carolina University · USGreenville College · USNew York Oncology Hematology · USUniversity of California, Los Angeles · USUniversity of Chicago · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
3-Way Approach for ED PreventionR01DK101536 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Carol Ann Podlasek · 2014 to 2026
$5.9M
NCI NIH HHS P30 CA008748NIDDK NIH HHS R01 DK101536
6 · The paper itself

Abstract

introductionThe biological importance of testosterone is generally accepted by the medical community; however, controversy focuses on its relevance to sexual function and the sexual response, and our understanding of the extent of its role in this area is evolving.

aimTo provide scientific evidence examining the role of testosterone at the cellular and molecular levels as it pertains to normal erectile physiology and the development of erectile dysfunction and to assist in guiding successful therapeutic interventions for androgen-dependent sexual dysfunction.

methodsIn this White Paper, the Basic Science Committee of the Sexual Medicine Society of North America assessed the current basic science literature examining the role of testosterone in sexual function and dysfunction.

resultsTestosterone plays an important role in sexual function through multiple processes: physiologic (stimulates activity of nitric oxide synthase), developmental (establishes and maintains the structural and functional integrity of the penis), neural (development, maintenance, function, and plasticity of the cavernous nerve and pelvic ganglia), therapeutically for dysfunctional regulation (beneficial effect on aging, diabetes, and prostatectomy), and phosphodiesterase type 5 inhibition (testosterone supplement to counteract phosphodiesterase type 5 inhibitor resistance).

conclusionDespite controversies concerning testosterone with regard to sexual function, basic science studies provide incontrovertible evidence for a significant role of testosterone in sexual function and suggest that properly administered testosterone therapy is potentially advantageous for treating male sexual dysfunction.

Indexed as

AndrogensErectile DysfunctionHumansMaleMuscle ContractionMuscle, SmoothNitric Oxide SynthaseNorth AmericaPenile ErectionPenisPhosphodiesterase 5 InhibitorsPostoperative ComplicationsPremature EjaculationProstatectomySexual BehaviorTestosteroneAndrogensNitric Oxide SynthasePhosphodiesterase 5 InhibitorsTestosteroneAgingAutonomic InputDevelopmentDiabetesMorphologyPenisPhosphodiesterase Type 5 InhibitorProstatectomyTestosterone

Identifiers

PMID27436075
PMCPMC5333763
OpenAlexW2478307126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.