ArticleJournal of biomedical optics2016
Differential diagnosis of breast masses in South Korean premenopausal women using diffuse optical spectroscopic imaging.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- AI-assisted diffuse correlation tomography for identifying breast cancer.Journal of biomedical optics · 2025Article
- Impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging for breast cancer.Scientific reports · 2025Article
- Innovative Discrete Multi-Wavelength Near-Infrared Spectroscopic (DMW-NIRS) Imaging for Rapid Breast Lesion Differentiation: Feasibility Study.Diagnostics (Basel, Switzerland) · 2025Article
- Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.Biomedical optics express · 2024Article
- Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer.Journal of biomedical optics · 2023Article
- Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics.Journal of biomedical optics · 2021Article
- Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions.Journal of biomedical optics · 2021Article
- Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data.Journal of biomedical optics · 2021Article
- Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging.Biomedical optics express · 2020Article
- Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trialJournal of biomedical optics · 2017Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Young patients with dense breasts have a relatively low-positive biopsy rate for breast cancer (∼1 in 7). South Korean women have higher breast density than Westerners. We investigated the benefit of using a functional and metabolic imaging technique, diffuse optical spectroscopic imaging (DOSI), to help the standard of care imaging tools to distinguish benign from malignant lesions in premenopausal Korean women. DOSI uses near-infrared light to measure breast tissue composition by quantifying tissue concentrations of water (ctH2O), bulk lipid (ctLipid), deoxygenated (ctHHb), and oxygenated (ctHbO2) hemoglobin. DOSI spectral signatures specific to abnormal tissue and absent in healthy tissue were also used to form a malignancy index. This study included 19 premenopausal subjects (average age 41±9), corresponding to 11 benign and 10 malignant lesions. Elevated lesion to normal ratio of ctH2O, ctHHb, ctHbO2, total hemoglobin (THb=ctHHb+ctHbO2), and tissue optical index (ctHHb×ctH2O/ctLipid) were observed in the malignant lesions compared to the benign lesions (p<0.02). THb and malignancy index were the two best single predictors of malignancy, with >90% sensitivity and specificity. Malignant lesions showed significantly higher metabolism and perfusion than benign lesions. DOSI spectral features showed high discriminatory power for distinguishing malignant and benign lesions in dense breasts of the Korean population.
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