ArticleScientific reports2016
Genomic content typifying a prevalent clade of bovine mastitis-associated Escherichia coli.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Comparative genomic analysis ofMicrobial genomics · 2025Article
- A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness.Animals : an open access journal from MDPI · 2025Review
- Virulence of Bacteria Causing Mastitis in Dairy Cows: A Literature Review.Microorganisms · 2025Review
- Involvement of adhesins (EcpD, FdeC, FimH) expressed in mammary pathogenic Escherichia coli on adhesion to bovine mammary epithelial cells.Antonie van Leeuwenhoek · 2024Article
- A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives.Microbiology spectrum · 2024Article
- Genes associated with fitness and disease severity in the pan-genome of mastitis-associatedFrontiers in microbiology · 2024Article
- Integrated analysis of inflammatory mRNAs, miRNAs, and lncRNAs elucidates the molecular interactome behind bovine mastitis.Scientific reports · 2023Article
- Fecal microbiome transplant from patients with lactation mastitis promotes mastitis in conventional lactating mice.Frontiers in microbiology · 2023Article
- Construction of the waaF Subunit and DNA Vaccine AgainstFrontiers in veterinary science · 2022Article
- Review
- Bile Salts Regulate Zinc Uptake and Capsule Synthesis in a Mastitis-Associated Extraintestinal Pathogenic Escherichia coli Strain.Infection and immunity · 2021Article
- Comparative genomic analysis ofMicrobial genomics · 2021Article
- Draft Genome Sequences of 113 Escherichia coli Strains Isolated from Intramammary Infections in Dairy Cattle.Microbiology resource announcements · 2021Article
- The role of O-polysaccharide chain and complement resistance of Escherichia coli in mammary virulence.Veterinary research · 2020Article
- Survey and Sequence Characterization of Bovine Mastitis-AssociatedFrontiers in veterinary science · 2020Article
- Molecular types, virulence profiles and antimicrobial resistance ofVeterinary record open · 2019Article
- Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis.Microbiome · 2018Article
- Article
- Genome-Wide Identification of Fitness Factors in Mastitis-Associated Escherichia coli.Applied and environmental microbiology · 2018Article
- Immunomodulation of Host Chitinase 3-Like 1 During a Mammary PathogenicFrontiers in immunology · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
E. coli represents a heterogeneous population with capabilities to cause disease in several anatomical sites. Among sites that can be colonised is the bovine mammary gland (udder) and a distinct class of mammary pathogenic E. coli (MPEC) has been proposed. MPEC are the principle causative agents of bovine mastitis in well-managed dairy farms, costing producers in the European Union an estimated €2 billion per year. Despite the economic impact, and the threat this disease presents to small and medium sized dairy farmers, the factors which mediate the ability for E. coli to thrive in bovine mammary tissue remain poorly elucidated. Strains belonging to E. coli phylogroup A are most frequently isolated from mastitis. In this paper, we apply a population level genomic analysis to this group of E. coli to uncover genomic signatures of mammary infectivity. Through a robust statistical analysis, we show that not all strains of E. coli are equally likely to cause mastitis, and those that do possess specific gene content that may promote their adaptation and survival in the bovine udder. Through a pan-genomic analysis, we identify just three genetic loci which are ubiquitous in MPEC, but appear dispensable for E. coli from other niches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.