ArticleEuropean radiology2017
Is there a difference in treatment outcomes between epidural injections with particulate versus non-particulate steroids?
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Comparison of epidural space contrast flow and clinical outcomes in parasagittal versus transforaminal epidural steroid injection.Scientific reports · 2026Trial
- Physician Perceptions of Particulate Versus Non-Particulate Steroids in Epidural Steroid Injections.Orthopedic reviews · 2026Article
- Epidural injection of dexamethasone palmitate vs. betamethasone for lumbar radiculopathy, study protocol for a multi-center non-inferiority randomized double-blind controlled trial.Frontiers in pharmacology · 2026Article
- Spine injections: the rationale for CT guidance.Skeletal radiology · 2023Review
- An update on epidural steroid injections: is there still a role for particulate corticosteroids?Skeletal radiology · 2023Review
- Transforaminal versus interlaminar CT-guided lumbar epidural steroid injections: prospective study of 237 patients with unilateral radicular pain and up to 5 years of follow-up.Skeletal radiology · 2023Article
- Article
- Predictive value of immediate pain relief after lumbar transforaminal epidural injection with local anesthetics and steroids for single level radiculopathy.Skeletal radiology · 2022Article
- CT-guided transforaminal epidural steroid injection for discogenic lumbar radiculopathy: influence of contrast dispersion and radiologist's experience on clinical outcome.Skeletal radiology · 2022Article
- Non-Particulate Steroids (Betamethasone Sodium Phosphate, Dexamethasone Sodium Phosphate, and Dexamethasone Palmitate) Combined with Local Anesthetics (Ropivacaine, Levobupivacaine, Bupivacaine, and Lidocaine): A Potentially Unsafe Mixture.Journal of pain research · 2021Article
- Pain reduction after lumbar epidural injections using particulate versus non-particulate steroids: intensity of the baseline pain matters.European radiology · 2019Observational
- Particulate versus non-particulate corticosteroids for transforaminal nerve root blocks: Comparison of outcomes in 494 patients with lumbar radiculopathy.European radiology · 2018Article
- Highlights of the annual scientific meeting of the 22nd congress of the European Society of Musculoskeletal Radiology (ESSR) 2015.Skeletal radiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the outcomes of patients after interlaminar computed tomography (CT)-guided epidural injections of the lumbar spine with particulate vs. non-particulate steroids.
methods531 consecutive patients were treated with CT-guided lumbar interlaminar epidural injections with steroids and local anaesthetics. 411 patients received a particulate steroid and 120 patients received a non-particulate steroid. Pain levels were assessed using the 11-point numerical rating scale (NRS) and overall reported 'improvement' was assessed using the Patients Global Impression of Change (PGIC) at 1 day, 1 week and 1 month post-injection. Descriptive and inferential statistics were applied.
resultsPatients receiving particulate steroids had statistically significantly higher NRS change scores (p = 0.0001 at 1 week; p = 0.0001 at 1 month). A significantly higher proportion of patients receiving particulate steroids reported relevant improvement (PGIC) at both 1 week and 1 month post injection (p = 0.0001) and they were significantly less likely to report worsening at 1 week (p = 0.0001) and 1 month (p = 0.017).
conclusionPatients treated with particulate steroids had significantly greater pain relief and were much more likely to report clinically relevant overall 'improvement' at 1 week and 1 month compared to the patients treated with non-particulate steroids. KEY POINTS: • CT-guided epidural injections of the lumbar spine with particulate vs. non-particulate steroids. • Good outcomes with particulate steroids. • Less pain relief in patients with non-particulate steroids. • Less improvement in patients with non-particulate steroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.