Evidence map›Paper›PMID 27435973›Full record

ArticleMalaria journal2016

Cytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-119 IgG antibody levels in a malaria-endemic area of the Brazilian Amazon.

Adriana A C Furini, Marcela P Capobianco, Luciane M Storti-Melo, Maristela G Cunha, Gustavo C Cassiano, Ricardo Luiz D Machado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Frequency ofMediators of inflammation · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Adriana A C FuriniDepartment of Dermatology, Infectious and Parasitic Diseases, São José do Rio Preto Medical School, São José do Rio Preto, São Paulo, Brazil. adriana.cruz.furini@gmail.com.
Marcela P CapobiancoDepartment of Biology, São Paulo State University, São José do Rio Preto, São Paulo, Brazil.
Luciane M Storti-MeloLaboratory of Molecular Genetics and Biotechnology, Department of Biology, Federal University of Sergipe, São Cristóvão, SE, Brazil.
Maristela G CunhaLaboratory of Microbiology and Immunology, Institute of Biological Sciences, Federal University of Pará (Universidade Federal do Pará-UFPA), Belém, State of Pará (PA), Brazil.
Gustavo C CassianoLaboratory of Tropical Diseases-Department of Genetics, Evolution and Bioagents, Universidade de Campinas, Campinas, SP, Brazil.
Ricardo Luiz D MachadoDepartment of Dermatology, Infectious and Parasitic Diseases, São José do Rio Preto Medical School, São José do Rio Preto, São Paulo, Brazil.
Faculdade de Medicina de São José do Rio Preto · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Sergipe · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe immune response against Plasmodium vivax immunogenic epitopes is regulated by pro- and anti-inflammatory cytokines that determine antibody levels and class switching. Cytokine gene polymorphisms may be responsible for changes in the humoral immune response against malaria. The aim of this study was to evaluate whether polymorphisms in the TNFA, IFNG and IL10 genes would alter the levels of anti-PvAMA1, PvDBP and -PvMSP-119 IgG antibodies in patients with vivax malaria.

methodsSamples from 90 vivax malaria-infected and 51 uninfected subjects from an endemic area of the Brazilian Amazon were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to identify polymorphisms of the genes TNFA (-1031T > C, -308G > A, -238G > A), IFNG (+874T > A) and IL10 (-819C > T, -592C > A). The levels of total IgG against PvAMA1, PvDBP and PvMSP-119 were determined using an enzyme-linked immunosorbent assay (ELISA). Associations between the polymorphisms and the antibody response were assessed by means of logistic regression models.

resultsNo significant differences were found in the levels of IgG antibodies against the PvAMA-1, PvDBP or PvMSP-119 proteins in relation to the studied polymorphisms.

conclusionsAlthough no associations were found among the evaluated genotypes and alleles and anti-merozoite IgG class P. vivax antibody levels, this study helps elucidate the immunogenic profile involved in the humoral immune response in malaria.

Indexed as

Polymorphism, GeneticAntibodies, ProtozoanAntigens, ProtozoanBrazilCytokinesEnzyme-Linked Immunosorbent AssayGenetic Association StudiesGenotyping TechniquesHumansImmunoglobulin GMembrane ProteinsPlasmodium vivaxPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthProtozoan ProteinsReceptors, Cell SurfaceAntibodies, ProtozoanAntigens, Protozoanapical membrane antigen I, PlasmodiumCytokinesDuffy antigen binding protein, PlasmodiumImmunoglobulin GMembrane ProteinsProtozoan ProteinsReceptors, Cell SurfaceIFNGIgG antibodyIL10Plasmodium vivaxTNF

Identifiers

PMID27435973
PMCPMC4952271
OpenAlexW2498652029

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.