ReviewAngewandte Chemie (International ed. in English)2016
New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis.
Review in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases.Nature communications · 2026Article
- Molecular Access Engineering for Microbial Biocatalysis: from Enzyme Tunnels to Microbial Cell Factories.Journal of microbiology and biotechnology · 2026Review
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Structure modification of an antibiotic: by engineering the fusaricidin bio-synthetase A inFrontiers in microbiology · 2023Article
- Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase.Chemical science · 2020Article
- Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.Natural product reports · 2020Review
- Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics.The Journal of biological chemistry · 2019Review
- The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase.Nature communications · 2019Article
- Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein.Biochemistry · 2019Article
- Article
- The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis.Chemical science · 2019Article
- Engineering of the Filamentous FungusFrontiers in microbiology · 2018Review
- FRET monitoring of a nonribosomal peptide synthetase.Nature chemical biology · 2017Article
- Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.Natural product reports · 2017Review
- Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication.The Journal of biological chemistry · 2017Article
- F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE.Scientific reports · 2016Article
- New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis.Angewandte Chemie (International ed. in English) · 2016Review
- Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934.Beilstein journal of organic chemistry · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nonribosomal peptide synthetases (NRPSs) are one of the most promising resources for the production of new bioactive molecules. The mechanism of NRPS catalysis is based around sequential catalytic domains: these are organized into modules, where each module selects, modifies, and incorporates an amino acid into the growing peptide. The intermediates formed during NRPS catalysis are delivered between enzyme centers by peptidyl carrier protein (PCP) domains, which makes PCP interactions and movements crucial to NRPS mechanism. PCP movement has been linked to the domain alternation cycle of adenylation (A) domains, and recent complete NRPS module structures provide support for this hypothesis. However, it appears as though the A domain alternation alone is insufficient to account for the complete NRPS catalytic cycle and that the loaded state of the PCP must also play a role in choreographing catalysis in these complex and fascinating molecular machines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.