ArticleScientific reports2016
A distinct brain pathway links viral RNA exposure to sickness behavior.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed.
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- Mast cells proliferate in the peri-hippocampal space during early development and modulate local and peripheral immune cells.Developmental cell · 2025Article
- AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects.Nature communications · 2024Article
- Article
- Evolutionary Aspects of Infections: Inflammation and Sickness Behaviors.Current topics in behavioral neurosciences · 2023Article
- Interaction of the pre- and postnatal environment in the maternal immune activation model.Discover mental health · 2023Review
- Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks.The journal of poultry science · 2023Review
- Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase.Scientific reports · 2022Article
- Sex differences and similarities in the neuroimmune response to central administration of poly I:C.Journal of neuroinflammation · 2021Article
- Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.Brain, behavior, and immunity · 2021Article
- Microglia depletion and alcohol: Transcriptome and behavioral profiles.Addiction biology · 2021Article
- Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age.bioRxiv : the preprint server for biology · 2021Article
- Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice.Molecular brain · 2020Article
- Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia.The Journal of clinical investigation · 2020Article
- Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer.eLife · 2020Article
- Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance.Brain, behavior, and immunity · 2019Article
- MyD88 signalling is critical in the development of pancreatic cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2019Article
- Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.Brain, behavior, and immunity · 2019Article
- Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake.Brain, behavior, and immunity · 2019Article
- Viral Mimetic-Induced Inflammation Abolishes Q-Pathway, but Not S-Pathway, Respiratory Motor Plasticity in Adult Rats.Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Sickness behaviors and metabolic responses to invading pathogens are common to nearly all types of infection. These responses evolved to provide short-term benefit to the host to ward off infection, but impact on quality of life, and when prolonged lead to neurodegeneration, depression, and cachexia. Among the major infectious agents, viruses most frequently enter the brain, resulting in profound neuroinflammation. We sought to define the unique features of the inflammatory response in the brain to these infections. We demonstrate that the molecular pathway defining the central response to dsRNA is distinct from that found in the periphery. The behavioral and physical response to the dsRNA mimetic poly I:C is dependent on signaling via MyD88 when it is delivered centrally, whereas this response is mediated via the TRIF pathway when delivered peripherally. We also define the likely cellular candidates for this MyD88-dependent step. These findings suggest that symptom management is possible without ameliorating protective antiviral immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.