ArticleBioengineered2016
Bioconversion of L-phenylalanine to 2-phenylethanol by the novel stress-tolerant yeast Candida glycerinogenes WL2002-5.
Article in Bioengineered, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Systematic process optimization for enhanced biosynthesis of 2-phenylethanol using Candida sorboxylosa.Bioprocess and biosystems engineering · 2026Article
- High-titer 2-phenylethanol production in Escherichia coli via decarboxylation-step optimization and a vegetable-oil overlay for biocompatible in situ recovery.Journal of biological engineering · 2026Article
- Solid/Gas Synthesis of Isobutyl Propionate Catalyzed by Packed-Bed CalB Cross-Linked Enzyme Aggregates (CLEA).ACS omega · 2025Article
- Enhanced multistress tolerance ofMicrobiology spectrum · 2025Article
- Microbial engineering for monocyclic aromatic compounds production.FEMS microbiology reviews · 2025Review
- Biotechnological 2-Phenylethanol Production: Recent Developments.Molecules (Basel, Switzerland) · 2024Review
- Comprehensive investigations of 2-phenylethanol production by the filamentous fungus Annulohypoxylon stygium.Applied microbiology and biotechnology · 2024Article
- Exploring the biotechnological potential ofBiotechnology reports (Amsterdam, Netherlands) · 2024Article
- Microbial Community Dynamics and the Correlation between Specific Bacterial Strains and Higher Alcohols Production in Tartary Buckwheat Huangjiu Fermentation.Foods (Basel, Switzerland) · 2023Article
- Systematic Adaptation of Bacillus licheniformis to 2-Phenylethanol Stress.Applied and environmental microbiology · 2023Article
- De novo Synthesis of 2-phenylethanol from Glucose by Metabolically Engineered Escherichia coli.Journal of industrial microbiology & biotechnology · 2023Article
- Genomic, transcriptomic, and metabolic characterization of 2-Phenylethanol-resistantFrontiers in microbiology · 2023Article
- Quorum sensing: cell-to-cell communication inFrontiers in microbiology · 2023Review
- Screening of Yeasts Isolated fromFoods (Basel, Switzerland) · 2022Article
- Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels.Engineering microbiology · 2022Review
- Bioproduction of 2-Phenylethanol through Yeast Fermentation on Synthetic Media and on Agro-Industrial Waste and By-Products: A Review.Foods (Basel, Switzerland) · 2022Review
- Sensing, Uptake and Catabolism of L-Phenylalanine During 2-Phenylethanol BiosynthesisFrontiers in microbiology · 2021Review
- EngineeringACS synthetic biology · 2020Article
- Screening of yeasts isolated from3 Biotech · 2020Article
- Transcription factor Hap5 induces gsh2 expression to enhance 2-phenylethanol tolerance and production in an industrial yeast Candida glycerinogenes.Applied microbiology and biotechnology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2-Phenylethanol (2-PE) is a high value aromatic alcohol with a rose-like odor that is utilized in the cosmetics and other industries. Although the chemical routes of 2-PE production have been altered by some microbial transformation processes, the poor tolerance to organic solvents of these microorganisms has limited the 2-PE yield. In this study, the stress-tolerant yeast Candida glycerinogenes WL2002-5 showed a 2-PE tolerance to 4 g/l, which is the highest reported to date. Moreover, the 2-PE titer in a batch fermentation from L-phenylalanine reached 5g/l, which is the highest level achieved by fermentation without in situ product recovery. These results suggest C. glycerinogenes WL2002-5 is a robust strain for the bioproduction of 2-PE with potential for commercial exploitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.