ArticleThe Journal of biological chemistry2016
dFOXO Activates Large and Small Heat Shock Protein Genes in Response to Oxidative Stress to Maintain Proteostasis in Drosophila.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Context-dependent toxicity of human tau isoforms in a Drosophila tauopathy model.Biology open · 2026Article
- Insulin Signaling Functions as a Topological Switch That Couples Aging and Heat Stress Responsiveness.bioRxiv : the preprint server for biology · 2026Article
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- CHIP and aging: a key regulator of proteostasis and cellular senescence.Biogerontology · 2025Review
- Effects of Environmentally Friendly Aquaculture Chamber Coatings on Enzyme Activities, Histology, and Transcriptome in the Liver of Larimichthys crocea.Marine biotechnology (New York, N.Y.) · 2025Article
- Climate Resilience in Farm Animals: Transcriptomics-Based Alterations in Differentially Expressed Genes and Stress Pathways.Biotech (Basel (Switzerland)) · 2024Review
- DNA damage signaling ineLife · 2024Article
- Article
- Dietary Sucrose Determines Stress Resistance, Oxidative Damages, and Antioxidant Defense System inScientifica · 2022Article
- Honey bee sHSP are responsive to diverse proteostatic stresses and potentially promising biomarkers of honey bee stress.Scientific reports · 2021Article
- FOXR1 regulates stress response pathways and is necessary for proper brain development.PLoS genetics · 2021Article
- Review
- Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster.Cell stress & chaperones · 2021Article
- A mild heat stress increases resistance to heat of dFOXO Drosophila melanogaster mutants but less in wild-type flies.Biogerontology · 2021Article
- Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage inFrontiers in cell and developmental biology · 2021Article
- Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO.Life science alliance · 2020Article
- Analysis of circulating-microRNA expression in lactating Holstein cows under summer heat stress.PloS one · 2020Article
- Review
- Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1).PloS one · 2018Article
- PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan ineLife · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Maintaining protein homeostasis is critical for survival at the cellular and organismal level (Morimoto, R. I. (2011) Cold Spring Harb. Symp. Quant. Biol. 76, 91-99). Cells express a family of molecular chaperones, the heat shock proteins, during times of oxidative stress to protect against proteotoxicity. We have identified a second stress responsive transcription factor, dFOXO, that works alongside the heat shock transcription factor to activate transcription of both the small heat shock protein and the large heat shock protein genes. This expression likely protects cells from protein misfolding associated with oxidative stress. Here we identify the regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.