Evidence map›Paper›PMID 27435624›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Multimodality imaging of blood-brain barrier impairment during epileptogenesis.

Heike Breuer, Martin Meier, Sophie Schneefeld, Wolfgang Härtig, Alexander Wittneben, Martin Märkel, Tobias L Ross, Frank M Bengel, Marion Bankstahl, Jens P Bankstahl

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Immune dysregulation and epileptogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  11. Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  12. Article
  13. Article
  14. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  15. Review
  16. Review
  17. Microvascular changes associated with epilepsy: A narrative review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Review
  18. Review
  19. Review
  20. Divergent metabolic substrate utilization in brain during epileptogenesis precedes chronic hypometabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Heike Breuer1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Martin Meier3 Preclinical Imaging Labs, Central Laboratory Animal Facility & Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
Sophie Schneefeld1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Wolfgang Härtig4 Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.
Alexander Wittneben1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Martin Märkel4 Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany.
Tobias L Ross1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Frank M Bengel1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Marion Bankstahl2 Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover and Center for Systems Neuroscience, Hannover, Germany.
Jens P Bankstahl1 Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DELeipzig University · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insult-associated blood-brain barrier leakage is strongly suggested to be a key step during epileptogenesis. In this study, we used three non-invasive translational imaging modalities, i.e. positron emission tomography, single photon emission computed tomography, and magnetic resonance imaging, to evaluate BBB leakage after an epileptogenic brain insult. Sprague-Dawley rats were scanned during early epileptogenesis initiated by status epilepticus. Positron emission tomography and single photon emission computed tomography scans were performed using the novel tracer [

Indexed as

AnimalsBlood-Brain BarrierCapillary Leak SyndromeCapillary PermeabilityEpilepsyFemaleMagnetic Resonance ImagingPositron-Emission TomographyRats, Sprague-DawleySensitivity and SpecificityTomography, Emission-Computed, Single-PhotonBlood–brain barrierepilepsyimagingmagnetic resonance imagingpositron emission tomography

Identifiers

PMID27435624
PMCPMC5464700
OpenAlexW2496420234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.