ArticleScientific reports2016
3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Integration of multi-modal monitoring for dynamic control of large-scale 3D tissue bioreactors.Scientific reports · 2026Article
- From Fundamentals of Laser-Induced Breakdown Spectroscopy to Recent Advancements in Cancer Detection and Calcified Tissues Analysis: An Overview (2015-2025).Molecules (Basel, Switzerland) · 2025Review
- Quantifying Titanium Exposure in Lung Tissues: A Novel Laser-Induced Breakdown Spectroscopy Elemental Imaging-Based Analytical Framework for Biomedical Applications.Small science · 2024Article
- Characterization of Functional Coatings on Cork Stoppers with Laser-Induced Breakdown Spectroscopy Imaging.Sensors (Basel, Switzerland) · 2023Article
- Expanding the boundaries of atomic spectroscopy at the single-cell level: critical review of SP-ICP-MS, LIBS and LA-ICP-MS advances for the elemental analysis of tissues and single cells.Analytical and bioanalytical chemistry · 2023Review
- Comparison of whole blood and serum samples of breast cancer based on laser-induced breakdown spectroscopy with machine learning.Biomedical optics express · 2023Article
- Stable sensing platform for diagnosing electrolyte disturbance using laser-induced breakdown spectroscopy.Biomedical optics express · 2022Article
- Anticancer Nanotherapeutics in Clinical Trials: The Work behind Clinical Translation of Nanomedicine.International journal of molecular sciences · 2022Review
- Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging.Biochemical pharmacology · 2022Review
- Predictive data clustering of laser-induced breakdown spectroscopy for brain tumor analysis.Biomedical optics express · 2021Article
- Study on the Molecular Mechanisms Against Human Breast Cancer from Insight of Elemental Distribution in Tissue Based on Laser-Induced Breakdown Spectroscopy (LIBS).Biological trace element research · 2021Article
- Methodology for the Implementation of Internal Standard to Laser-Induced Breakdown Spectroscopy Analysis of Soft Tissues.Sensors (Basel, Switzerland) · 2021Article
- 3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography.Frontiers in oncology · 2021Article
- Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution.Nanoscale advances · 2020Article
- Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications.Cells · 2020Article
- Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Laser-induced breakdown spectroscopy as a novel readout method for nanoparticle-based immunoassays.Mikrochimica acta · 2019Article
- Elemental imaging by Laser-Induced Breakdown Spectroscopy to evaluate selenium enrichment effects in edible mushrooms.Scientific reports · 2019Article
- AGuIXThe British journal of radiology · 2019Review
- Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomaterials represent a rapidly expanding area of research with huge potential for future medical applications. Nanotechnology indeed promises to revolutionize diagnostics, drug delivery, gene therapy, and many other areas of research. For any biological investigation involving nanomaterials, it is crucial to study the behavior of such nano-objects within tissues to evaluate both their efficacy and their toxicity. Here, we provide the first account of 3D label-free nanoparticle imaging at the entire-organ scale. The technology used is known as laser-induced breakdown spectroscopy (LIBS) and possesses several advantages such as speed of operation, ease of use and full compatibility with optical microscopy. We then used two different but complementary approaches to achieve 3D elemental imaging with LIBS: a volume reconstruction of a sliced organ and in-depth analysis. This proof-of-concept study demonstrates the quantitative imaging of both endogenous and exogenous elements within entire organs and paves the way for innumerable applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.