Evidence map›Paper›PMID 27435343›Full record

ArticleNanoscale research letters2016

Construction and Immunological Evaluation of CpG-Au@HBc Virus-Like Nanoparticles as a Potential Vaccine.

Yarun Wang, Yue Wang, Ning Kang, Yongliang Liu, Wenjun Shan, Shengli Bi, Lei Ren, Guohong Zhuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale research letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Topical review on nano-vaccinology: Biochemical promises and key challenges.Process biochemistry (Barking, London, England) · 2021
    Review
  5. CpG-Based Nanovaccines for Cancer Immunotherapy.International journal of nanomedicine · 2021
    Review
  6. Review
  7. Review
  8. Article
  9. Development of Peptide Vaccines in Dengue.Current pharmaceutical design · 2018
    Review
  10. Review
  11. Article
  12. Pulmonary Delivery of Nonviral Nucleic Acid-Based Vaccines With Spotlight on Gold Nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yarun WangDepartment of Biomaterials and Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China.
Yue WangOrgan Transplantation Institute, Anti-Cancer Research Center, Medical College, Xiamen University, Xiamen, 361005, People's Republic of China.
Ning KangDepartment of Biomaterials and Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China.
Yongliang LiuDepartment of Biomaterials and Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China.
Wenjun ShanDepartment of Biomaterials and Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China.
Shengli BiNational Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention, Changbai Road 155, Changping District, Beijing, 102206, People's Republic of China.
Lei RenDepartment of Biomaterials and Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China. renlei@xmu.edu.cn.
Guohong ZhuangOrgan Transplantation Institute, Anti-Cancer Research Center, Medical College, Xiamen University, Xiamen, 361005, People's Republic of China. zhgh@xmu.edu.cn.
Xiamen University · CNNational Institute for Viral Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different types of vaccines have been developed to elicit active immunization to treat various diseases, while suffer from limitation of efficacy. Herein, a novel immunostimulatory nanocomposite (CpG-Au@HBc VLP) was rationally designed by self-assembling engineered virus-like particles encapsulating CpG-gold nanoparticle conjugates through electrostatic interactions. The monodispersed and uniformly sized CpG-Au@HBc VLP showed increased CD4(+), CD8(+) T cell numbers and stronger secretion of cytokine interferon-gamma than HBc VLPs adjuvanted with conventional Freund's adjuvant. Furthermore, the use of Au nanoparticles also generated enhanced immunogenicity of CpG and VLPs on both humoral and cellular immune pathways, as followed from increased expressions of total HBc-specific antibody titer, CD4(+) T cells, CD8(+) T cells, cytokine interleukin-4, and interferon-gamma. These findings demonstrated that CpG-Au@HBc VLP nanocomposite could induce robust cellular and humoral immune response, which could be a potential vaccine for future prophylactic and therapeutic application.

Indexed as

CpG ODNsGold nanoparticlesImmune responseVirus-like nanoparticles

Identifiers

PMID27435343
PMCPMC4951386
OpenAlexW2505761802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.