Evidence map›Paper›PMID 27435230›Full record

ArticleThe international journal of cardiovascular imaging2016

Comparison of 4D flow and 2D velocity-encoded phase contrast MRI sequences for the evaluation of aortic hemodynamics.

Emilie Bollache, Pim van Ooij, Alex Powell, James Carr, Michael Markl, Alex J Barker

Abstract readComparative Study
In one paragraph

Article in The international journal of cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Guideline
  2. Comparison of free-running whole-heart five-dimensional and four-dimensional flow imaging to standard two-dimensional flow in patients with congenital heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  3. Article
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  5. Review
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Review
  19. Clinical Applications of 4D Flow MR Imaging in Aortic Valvular and Congenital Heart Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emilie BollacheDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA. emilie.bollache@northwestern.edu.
Pim van OoijDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA.
Alex PowellDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA.
James CarrDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA.
Michael MarklDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA.
Alex J BarkerDepartment of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan ave-Suite 1600, Chicago, IL, 60611, USA.

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
Hemodynamic Loading of the Left Ventricle and Aorta in Aortic Valve DiseaseK25HL119608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J. · 2014 to 2018
$819k
NHLBI NIH HHS K25 HL119608NHLBI NIH HHS R01 HL115828
6 · The paper itself

Abstract

The purpose of this study was to compare aortic flow and velocity quantification using 4D flow MRI and 2D CINE phase-contrast (PC)-MRI with either one-directional (2D-1dir) or three-directional (2D-3dir) velocity encoding. 15 healthy volunteers (51 ± 19 years) underwent MRI including (1) breath-holding 2D-1dir and (2) free breathing 2D-3dir PC-MRI in planes orthogonal to the ascending (AA) and descending (DA) aorta, as well as (3) free breathing 4D flow MRI with full thoracic aorta coverage. Flow quantification included the co-registration of the 2D PC acquisition planes with 4D flow MRI data, AA and DA segmentation, and calculation of AA and DA peak systolic velocity, peak flow and net flow volume for all sequences. Additionally, the 2D-3dir velocity taking into account the through-plane component only was used to obtain results analogous to a free breathing 2D-1dir acquisition. Good agreement was found between 4D flow and 2D-3dir peak velocity (differences = -3 to 6 %), peak flow (-7 %) and net volume (-14 to -9 %). In contrast, breath-holding 2D-1dir measurements exhibited indices significantly lower than free breathing 2D-3dir and 2D-1dir (differences = -35 to -7 %, p < 0.05). Finally, high correlations (r ≥ 0.97) were obtained for indices estimated with or without eddy current correction, with the lowest correlation observed for net volume. 4D flow and 2D-3dir aortic hemodynamic indices were in concordance. However, differences between respiration state and 2D-1dir and 2D-3dir measurements indicate that reference values should be established according to the PC-MRI sequence, especially for the widely used net flow (e.g. stroke volume in the AA).

Indexed as

AlgorithmsHemodynamicsAdultAgedAorta, ThoracicBlood Flow VelocityFemaleHealthy VolunteersHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsRegional Blood FlowReproducibility of Results4D flow MRIAortic hemodynamicsMRIPhase-contrast

Identifiers

PMID27435230
PMCPMC5096729

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.