Evidence map›Paper›PMID 27434804›Full record

ArticleJournal of mass spectrometry : JMS2016

Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.

Stephen Barnes, H Paul Benton, Krista Casazza, Sara J Cooper, Xiangqin Cui, Xiuxia Du, Jeffrey Engler, Janusz H Kabarowski, Shuzhao Li, Wimal Pathmasiri and 3 more

Abstract read
In one paragraph

Article in Journal of mass spectrometry : JMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 84 citations in OpenAlex.

  1. Trial
  2. Article
  3. Metabolomics and Biomarker Discovery.Advances in experimental medicine and biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. A Proteogenomic Approach to Unveiling the Complex Biology of the Microbiome.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Advances in Microbial NMR Metabolomics.Advances in experimental medicine and biology · 2023
    Article
  16. Article
  17. Review
  18. Dietary Oxidized Linoleic Acids Modulate Fatty Acids in Mice.Journal of lipid and atherosclerosis · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Stephen BarnesDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
H Paul BentonScripps Research Institute, La Jolla, CA, 92307, USA.
Krista CasazzaDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Sara J CooperHudsonAlpha Institute, Huntsville, AL, 35806, USA.
Xiangqin CuiSection on Statistical Genetics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Xiuxia DuDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA.
Jeffrey EnglerDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Janusz H KabarowskiDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Shuzhao LiDepartment of Medicine, Emory University, Atlanta, GA, 30322, USA.
Wimal PathmasiriRTI International, Research Triangle Park, Durham, NC, 27709, USA.
Jeevan K PrasainDepartment of Pharmacology and Toxicology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Matthew B RenfrowDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Hemant K TiwariSection on Statistical Genetics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
University of Alabama at Birmingham · USEmory University · USHudsonAlpha Institute for Biotechnology · USRTI International · USScripps Research Institute · USTarget (United States) · USUniversity of North Carolina at Charlotte · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MICHAEL JAMES BERTRAM · 1985 to 2026
$165.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SANDERS, PAUL W. · 2008 to 2022
$18.3M
UAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4M
Molecular determinants of breast cancer malignancyR01CA138850 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SHEVDE, LALITA A. · 2011 to 2015
$1.6M
Mechanisms of glucose mediated cardiac mitochondrial dysfunctionR00HL111322 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WENDE, ADAM RAYMOND · 2013 to 2015
$870k
"UAB Metabolomics Workshop: from design to decision"R25GM103798 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, STEPHEN · 2012 to 2016
$483k
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA138850NHLBI NIH HHS R00 HL111322NIDDK NIH HHS P30 DK079337NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P60 DK079626NIGMS NIH HHS R25 GM103798
6 · The paper itself

Abstract

The study of metabolism has had a long history. Metabolomics, a systems biology discipline representing analysis of known and unknown pathways of metabolism, has grown tremendously over the past 20 years. Because of its comprehensive nature, metabolomics requires careful consideration of the question(s) being asked, the scale needed to answer the question(s), collection and storage of the sample specimens, methods for extraction of the metabolites from biological matrices, the analytical method(s) to be employed and the quality control of the analyses, how collected data are correlated, the statistical methods to determine metabolites undergoing significant change, putative identification of metabolites and the use of stable isotopes to aid in verifying metabolite identity and establishing pathway connections and fluxes. The National Institutes of Health Common Fund Metabolomics Program was established in 2012 to stimulate interest in the approaches and technologies of metabolomics. To deliver one of the program's goals, the University of Alabama at Birmingham has hosted an annual 4-day short course in metabolomics for faculty, postdoctoral fellows and graduate students from national and international institutions. This paper is the first part of a summary of the training materials presented in the course to be used as a resource for all those embarking on metabolomics research. The complete set of training materials including slide sets and videos can be viewed at http://www.uab.edu/proteomics/metabolomics/workshop/workshop_june_2015.php. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

AnimalsChromatography, LiquidElectrophoresis, CapillaryGas Chromatography-Mass SpectrometryHumansMagnetic Resonance SpectroscopyMass SpectrometryMetabolomeMetabolomicsResearch DesignCE-MSGC-MSLC-MSmetabolomicsNMRsample extractionstudy design

Identifiers

PMID27434804
PMCPMC4964969
OpenAlexW3178385266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.