ArticleeLife2016
Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- A novel mechanism for ramping bursts based on slow negative feedback in model respiratory neurons.Chaos (Woodbury, N.Y.) · 2024Article
- Interdependence of cellular and network properties in respiratory rhythm generation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interdependence of cellular and network properties in respiratory rhythmogenesis.bioRxiv : the preprint server for biology · 2023Article
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Role of NaCell reports · 2023Article
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
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- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development.Respiratory physiology & neurobiology · 2019Review
- Robustness of respiratory rhythm generation across dynamic regimes.PLoS computational biology · 2019Article
- Article
- Hindbrain V2a Neurons Pattern Rhythmic Activity of Motor Neurons in a Reticulospinal Coculture.Frontiers in neuroscience · 2019Article
- Perinatal Breathing Patterns and Survival in Mice Born Prematurely and at Term.Frontiers in physiology · 2019Article
- Breathing matters.Nature reviews. Neuroscience · 2018Review
- Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.eLife · 2016Article
- Vertebrate Evolution Conserves Hindbrain Circuits despite Diverse Feeding and Breathing Modes.eNeuroReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Breathing is a vital rhythmic behavior generated by hindbrain neuronal circuitry, including the preBötzinger complex network (preBötC) that controls inspiration. The emergence of preBötC network activity during prenatal development has been described, but little is known regarding inspiratory neurons expressing pacemaker properties at embryonic stages. Here, we combined calcium imaging and electrophysiological recordings in mouse embryo brainstem slices together with computational modeling to reveal the existence of heterogeneous pacemaker oscillatory properties relying on distinct combinations of burst-generating INaP and ICAN conductances. The respective proportion of the different inspiratory pacemaker subtypes changes during prenatal development. Concomitantly, network rhythmogenesis switches from a purely INaP/ICAN-dependent mechanism at E16.5 to a combined pacemaker/network-driven process at E18.5. Our results provide the first description of pacemaker bursting properties in embryonic preBötC neurons and indicate that network rhythmogenesis undergoes important changes during prenatal development through alterations in both circuit properties and the biophysical characteristics of pacemaker neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.