ArticlePloS one2016
Comparative Analysis of Secretome Profiles of Manganese(II)-Oxidizing Ascomycete Fungi.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Multi-omics insights into bacterial and fungal bioremediation of Potentially Toxic Elements (PTEs): a critical overview of their applications.World journal of microbiology & biotechnology · 2026Review
- Synergy between reactive manganese species and enzymes drives litter decomposition hotspots.Nature communications · 2026Article
- Manganese(II)-oxidizing Ascomycete fungi experience growth benefit on polyphenolic substrate.FEMS microbiology ecology · 2026Article
- Genome assembly and comparative analysis of Alternaria Linariae reveal novel genes associated with host colonization and virulence.BMC genomics · 2025Article
- Mycotransformation of anthracene by indigenous Trichoderma lixii and Talaromyces pinophilus isolates: insights into the metabolic pathways, enzyme profiles and acute toxicity.Biodegradation · 2025Article
- Argonaute and Dicer are essential for communication betweenMicrobiology spectrum · 2024Article
- Genomic and transcriptomic analysis of camptothecin producing novel fungal endophyte: Alternaria burnsii NCIM 1409.Scientific reports · 2023Article
- Variability of Functional Groups of Rhizosphere Fungi of Norway Spruce (International journal of molecular sciences · 2023Article
- Changes in Bulk and Rhizosphere Soil Microbial Diversity Communities of Native Quinoa Due to the Monocropping in the Peruvian Central Andes.Microorganisms · 2023Article
- The First Telomere-to-Telomere Chromosome-Level Genome Assembly ofJournal of fungi (Basel, Switzerland) · 2022Article
- Fungal perylenequinones.Mycological progress · 2022Review
- Identification of Copper-Containing Oxidoreductases in the Secretomes of ThreeApplied and environmental microbiology · 2021Article
- Cryptic genetic structure and copy-number variation in the ubiquitous forest symbiotic fungus Cenococcum geophilum.Environmental microbiology · 2021Article
- Genome sequences and in silico effector mining of Corynespora cassiicola CC_29 and Corynespora olivacea CBS 114450.Archives of microbiology · 2021Article
- Increased abundance of secreted hydrolytic enzymes and secondary metabolite gene clusters define the genomes of latent plant pathogens in the Botryosphaeriaceae.BMC genomics · 2021Article
- Whole Genome Sequence ofFrontiers in microbiology · 2021Article
- Mechanisms of Manganese(II) Oxidation by Filamentous Ascomycete Fungi Vary With Species and Time as a Function of Secretome Composition.Frontiers in microbiology · 2021Article
- Article
- 101Studies in mycology · 2020Article
- Mycoparasitism illuminated by genome and transcriptome sequencing ofMicrobial genomics · 2020Article
Corrections and comments
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal secretomes contain a wide range of hydrolytic and oxidative enzymes, including cellulases, hemicellulases, pectinases, and lignin-degrading accessory enzymes, that synergistically drive litter decomposition in the environment. While secretome studies of model organisms such as Phanerochaete chrysosporium and Aspergillus species have greatly expanded our knowledge of these enzymes, few have extended secretome characterization to environmental isolates or conducted side-by-side comparisons of diverse species. Thus, the mechanisms of carbon degradation by many ubiquitous soil fungi remain poorly understood. Here we use a combination of LC-MS/MS, genomic, and bioinformatic analyses to characterize and compare the protein composition of the secretomes of four recently isolated, cosmopolitan, Mn(II)-oxidizing Ascomycetes (Alternaria alternata SRC1lrK2f, Stagonospora sp. SRC1lsM3a, Pyrenochaeta sp. DS3sAY3a, and Paraconiothyrium sporulosum AP3s5-JAC2a). We demonstrate that the organisms produce a rich yet functionally similar suite of extracellular enzymes, with species-specific differences in secretome composition arising from unique amino acid sequences rather than overall protein function. Furthermore, we identify not only a wide range of carbohydrate-active enzymes that can directly oxidize recalcitrant carbon, but also an impressive suite of redox-active accessory enzymes that suggests a role for Fenton-based hydroxyl radical formation in indirect, non-specific lignocellulose attack. Our findings highlight the diverse oxidative capacity of these environmental isolates and enhance our understanding of the role of filamentous Ascomycetes in carbon turnover in the environment.
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