ArticlePloS one2016
2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in Arabidopsis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- History and current status of embryogenic culture-based tissue culture, transformation and gene editing of maize (Zea mays L.).The plant genome · 2025Review
- Slow release of a synthetic auxin induces formation of adventitious roots in recalcitrant woody plants.Nature biotechnology · 2024Article
- Synthesis of magnetic FeRSC advances · 2024Article
- Endogenous auxin maintains embryonic cell identity and promotes somatic embryo development in Arabidopsis.The Plant journal : for cell and molecular biology · 2023Article
- Transcriptional activation of auxin biosynthesis drives developmental reprogramming of differentiated cells.The Plant cell · 2022Article
- Potassium Chloroaurate-MediatedNanomaterials (Basel, Switzerland) · 2022Article
- Integrating the Roles for Cytokinin and Auxin in De Novo Shoot Organogenesis: From Hormone Uptake to Signaling Outputs.International journal of molecular sciences · 2021Review
- Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies.Nature communications · 2020Article
- Current Perspectives on the Auxin-Mediated Genetic Network that Controls the Induction of Somatic Embryogenesis in Plants.International journal of molecular sciences · 2020Review
- Anise-cultured cells abolish 2,4-dichlorophenoxyacetic acid in culture medium.Plant biotechnology (Tokyo, Japan) · 2019Article
- Modification of auxinic phenoxyalkanoic acid herbicides by the acyl acid amido synthetase GH3.15 from Arabidopsis.The Journal of biological chemistry · 2018Article
- Is auxin involved in the induction of genetic instability in barley homeotic double mutants?Planta · 2018Article
- Auxin signaling: a big question to be addressed by small molecules.Journal of experimental botany · 2018Review
- Control of Endogenous Auxin Levels in Plant Root Development.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The herbicide 2,4-D exhibits an auxinic activity and therefore can be used as a synthetic and traceable analog to study auxin-related responses. Here we identified that not only exogenous 2,4-D but also its amide-linked metabolite 2,4-D-Glu displayed an inhibitory effect on plant growth via the TIR1/AFB auxin-mediated signaling pathway. To further investigate 2,4-D metabolite conversion, identity and activity, we have developed a novel purification procedure based on the combination of ion exchange and immuno-specific sorbents combined with a sensitive liquid chromatography-mass spectrometry method. In 2,4-D treated samples, 2,4-D-Glu and 2,4-D-Asp were detected at 100-fold lower concentrations compared to 2,4-D levels, showing that 2,4-D can be metabolized in the plant. Moreover, 2,4-D-Asp and 2,4-D-Glu were identified as reversible forms of 2,4-D homeostasis that can be converted to free 2,4-D. This work paves the way to new studies of auxin action in plant development.
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Registered trials
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