SynthesisPloS one2016
Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The prevalence and odds of bipolar disorder in women with polycystic ovary syndrome (PCO) disease: a systematic review and meta-analysis.Archives of women's mental health · 2024Pooled it
- Age at menarche and risk of multiple sclerosis (MS): a systematic review and meta-analysis.BMC neurology · 2019Pooled it
- The association of toll-like receptor 4 gene polymorphisms with primary open angle glaucoma susceptibility: a meta-analysis.Bioscience reports · 2019Pooled it
- The associations between Toll-like receptor 4 gene polymorphisms and hepatitis C virus infection: a systematic review and meta-analysis.Bioscience reports · 2019Pooled it
- Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis.BMC ophthalmology · 2017Pooled it
- Pooled it
- Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Article
- Molecular Role of Asn680Ser and Asp37Glu Missense Variants in Saudi Women with Female Infertility and Polycystic Ovarian Syndrome.Current issues in molecular biology · 2023Article
- Is Celiac Disease (CD) Prevalent in Patients with Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis.Multiple sclerosis international · 2022Review
- Pregnancy History, Oral Contraceptive Pills Consumption (OCPs), and Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis.International journal of preventive medicine · 2022Review
- The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.Disease markers · 2021Article
- Association of Plasma Renalase and Left Ventricle Mass Index in Heart Failure Patients Stratified to the Category of the Ejection Fraction: A Pilot Study.Disease markers · 2019Article
- Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability.EBioMedicine · 2018Article
- Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Extracellular renalase protects cells and organs by outside-in signalling.Journal of cellular and molecular medicine · 2017Review
- Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.PloS one · 2017Article
- Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis.Clinical interventions in aging · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTwo renalase single nucleotide polymorphisms (SNPs) rs2296545 and rs2576178 have been reported to be associated with the susceptibility to hypertension (HT). Given the inconsistent results, we conducted a meta-analysis to assess the association between these two SNPs and the risk of HT.
methodsElectronic databases were systematically searched to find relevant studies. Subgroup analysis was conducted according to the different concomitant diseases and ethnicities in the study population. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated using fixed-effect or random-effect models.
resultsA total of six case-control studies on rs2296545 and six studies on rs2576178 were included. In the combined analysis, results showed a significant association between SNP rs2296545 and risk of HT in all genetic models (dominant model CG+CC/GG: OR = 1.43, 95% CI = 1.24-1.65; recessive model CC/CG+GG: OR = 1.36, 95% CI = 1.09-1.69; codominant model CC/GG: OR = 1.63, 95% CI = 1.20-2.20, CG/GG: OR = 1.30, 95% CI = 1.12-1.52; allelic model C/G: OR = 1.29, 95% CI = 1.10-1.51). In subgroup analysis, we observed a significant association between rs2296545 and risk of essential HT. Although we did not observe an association between rs2576178 polymorphism and HT in the combined analysis, an increased risk was observed in the essential HT patients versus healthy controls (subgroup 1) analysis under the dominant, recessive, and codominant genetic models.
conclusionsRenalase gene rs2296545 polymorphism is significantly associated with increased risk of HT, whereas rs2576178 polymorphism may not be associated with the susceptibility to HT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.