ArticlePediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2016
Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays.
Article in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Article
- Circulating proteins associated with allergy development in infants-an exploratory analysis.Clinical proteomics · 2021Article
- Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma.American journal of respiratory cell and molecular biology · 2018Article
- Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis.International journal of immunopathology and pharmacologyArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProteomic approaches identifying biomarkers have been applied to asthma to only a very limited extent.
methodsWith an antibody array (RayBiotech, Norcross, GA, USA), the relative intensity and rank differences of 444 proteins were compared in 24 plasma samples obtained at age 3, 11 from children with and 12 without asthma diagnoses at ages 5 and 9. Protein candidates identified by antibody array were quantitated by ELISA in an enlarged sample. Proteins found to differentiate children with and without asthma were also examined for association with known Year 1 asthma risk factors, eczema, and wheeze.
resultsIn the antibody array, four proteins had rank differences between asthma and non-asthma groups (FDR <0.1). By ELISA, mean log (±s.e.m.) erythropoietin (EPO) level (IU/l) was lower (0.750 ± 0.048 vs. 0.898 ± 0.035; p = 0.006) and mean (±s.e.m.) soluble GP130 (sGP130) level (ng/ml) was higher in the asthma vs. the non-asthma group (302 ± 13 vs. 270 ± 8; p = 0.041). The other 2 array proteins (galactin-3 and eotaxin-3) did not differ by ELISA by asthma. EPO related to the asthma risk factor, first year eczema, whereas sGP130 related to first year wheeze.
conclusionsThrough two independent assessments, age 3 plasma levels of EPO and sGP130 were found related to childhood asthma.
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