ArticleJournal of hypertension2016
High blood pressure as a risk factor for incident stroke among very old people: a population-based cohort study.
Article in Journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Incidence and predictors of stroke among hypertension patients in Awi Zone public hospitals, Northwest Ethiopia: Retrospective follow-up study.BMC cardiovascular disorders · 2026Article
- Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis.Scientific reports · 2025Article
- Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study.Human molecular genetics · 2024Article
- CVD incidence and mortality among people with diabetes and/or hypertension: Results from the English longitudinal study of ageing.PloS one · 2024Article
- Novel insight into the etiology of ischemic stroke gained by integrative transcriptome-wide association study.medRxiv : the preprint server for health sciences · 2023Article
- Associations of multiple chronic disease and depressive symptoms with incident stroke among Chinese middle-aged and elderly adults: a nationwide population-based cohort study.BMC geriatrics · 2022Article
- Age-related iron accumulation and demyelination in the basal ganglia are closely related to verbal memory and executive functioning.Scientific reports · 2021Article
- A retrospective study of Yiqi-Huoxue Decoction on blood pressure in patients with acute ischemic stroke.Medicine · 2020Article
- NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.PLoS biology · 2020Article
- Microarray Data Analysis of Molecular Mechanism Associated with Stroke Progression.Journal of molecular neuroscience : MN · 2019Article
- The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity.Journal of obesity · 2018Article
- Systolic blood pressure decline in very old individuals is explained by deteriorating health: Longitudinal changes from Umeå85+/GERDA.Medicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHigh blood pressure (BP) increases the risk of stroke, but there is limited evidence from studies including very old people. The aim was to investigate risk factors for incident stroke among very old people.
methodsA prospective population-based cohort study was performed among participants aged at least 85 years in northern Sweden. The 955 participants were tested at their homes. BP was measured manually after 5-min supine rest. Incident stroke data were collected from medical charts guided by hospital registry, death records, and 5-year reassessments. Cox proportional hazards models were used.
resultsThe stroke incidence was 33.8/1000 person-years (94 stroke events) during a mean follow-up period of 2.9 years. In a comprehensive multivariate model, atrial fibrillation [hazard ratio 1.85, 95% confidence interval (CI) 1.07-3.19] and higher SBP (hazard ratio 1.19, 95% CI 1.08-1.30 per 10-mmHg increase) were associated with incident stroke overall. However, higher SBP was not associated with incident stroke in participants with SBP less than 140 mmHg (hazard ratio 0.90, 95% CI 0.53-1.53 per 10-mmHg increase). In additional multivariate models, DBP at least 90 mmHg (hazard ratio 2.45, 95% CI 1.47-4.08) and SBP at least 160 mmHg (vs. <140 mmHg; hazard ratio 2.80, 95% CI 1.53-5.14) were associated with incident stroke. The association between BP and incident stroke was not affected by interactions related to sex, dependence in activities of daily living, or cognitive impairment.
conclusionHigh SBP (≥160 mmHg) and DBP (≥90 mmHg) and atrial fibrillation appeared to be risk factors for incident stroke among very old people.
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