Observational studyEmerging infectious diseases2016
Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated Plasmodium falciparum Malaria.
Observational study in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2019Trial
- Effect of Artemisia annua and Artemisia afra tea infusions on schistosomiasis in a large clinical trial.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2018Trial
- Article
- Malaria.The New England journal of medicine · 2025Review
- Recurrent Plasmodium falciparum Malaria in U.S. Travelers Treated with Artemether-Lumefantrine.The American journal of tropical medicine and hygiene · 2025Article
- Inhibition of Complement Will Substantially Reduce the Anemia of Malaria.Journal of immunology research · 2025Review
- Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Review
- Post-treatment haemolysis is common following oral artemisinin combination therapy of uncomplicated malaria in travellers.Journal of travel medicine · 2023Observational
- Imported severe Plasmodium falciparum infection in the first trimester of pregnancy complicated by post-artemisinin delayed hemolysis and intrauterine fetal death, a case report.Tropical medicine and health · 2023Article
- Plasmodium falciparum-Induced Autoimmune Hemolytic Anemia in a Pregnant Patient with Sickle Cell Disease.The American journal of case reports · 2023Article
- Post-Artesunate Delayed Hemolysis: A Review of Current Evidence.Tropical medicine and infectious disease · 2023Review
- Recent Advances in the Therapeutic Efficacy of Artesunate.Pharmaceutics · 2022Review
- The sting in the tail of severe falciparum malaria: Post-artesunate delayed haemolysis.Southern African journal of infectious diseases · 2022Article
- The Brief Case: A 6-Year-Old with Fever, Abdominal Pain, and Recent Travel to Sierra Leone.Journal of clinical microbiology · 2021Article
- Case Report: Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for UncomplicatedFrontiers in medicine · 2021Article
- Delayed haemolysis after treatment with intravenous artesunate in patients with severe malaria in India.Malaria journal · 2020Observational
- Article
- Artenimol-piperaquine in children with uncomplicated imported falciparum malaria: experience from a prospective cohort.Malaria journal · 2019Observational
- [PGE1-assisted treatment of microcirculation disturbance in complicated falciparum malaria].Der Anaesthesist · 2019Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment hemolysis also occurs after oral artemisinin-based combination therapy. Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level and increased lactate dehydrogenase level on day 14). Five patients had hemolysis persisting for 1 month. Patients with posttreatment hemolysis had a median decrease in hemoglobin level of 1.3 g/dL (interquartile range 0.3-2.0 g/dL) in the posttreatment period, and patients without posttreatment hemolysis had a median increase of 0.3 g/dL (IQR -0.1 to 0.7 g/dL; p = 0.002). These findings indicate a need for increased vigilance for hemolytic events in malaria patients, particularly those with predisposing factors for anemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.