ArticlePloS one2016
Single- and Bayesian Multi-Marker Genome-Wide Association for Haematological Parameters in Pigs.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Haematopoietic Traits in Indigenous and Modern Pig Breeds Are Modulated by Housing System and Developmental Stage.Animal genetics · 2026Article
- Genetic factors for hematological traits in pigs.Animal genetics · 2025Review
- Multivariate genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2023Article
- Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs.Genetics, selection, evolution : GSE · 2022Article
- Comparison of the choice of animals for re-sequencing in two maternal pig lines.Genetics, selection, evolution : GSE · 2022Article
- Expression Profiles of the OvineFrontiers in veterinary science · 2022Article
- Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs.Animal microbiome · 2021Article
- Genome-wide associations for immune traits in two maternal pig lines.BMC genomics · 2021Article
- Article
- Investigation of Early Supplementation of Nucleotides on the Intestinal Maturation of Weaned Piglets.Animals : an open access journal from MDPI · 2021Article
- Genome-Wide Identification of Candidate Genes for Milk Production Traits in Korean Holstein Cattle.Animals : an open access journal from MDPI · 2021Article
- A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs.Frontiers in immunology · 2021Article
- Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs.Scientific reports · 2020Article
- Genome-wide association studies for 30 haematological and blood clinical-biochemical traits in Large White pigs reveal genomic regions affecting intermediate phenotypes.Scientific reports · 2019Article
- Imputation-Based Whole-Genome Sequence Association Study Reveals Constant and Novel Loci for Hematological Traits in a Large-Scale Swine FFrontiers in genetics · 2018Article
- Genetics of body fat mass and related traits in a pig population selected for leanness.Scientific reports · 2017Article
- Genome-Wide Association Study of Piglet Uniformity and Farrowing Interval.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haematological traits are important traits that show associations with immune and metabolic status, as well as diseases in humans and animals. Mapping genome regions that affect the blood cell traits can contribute to the identification of genomic features useable as biomarkers for immune, disease and metabolic status. A genome-wide association study (GWAS) was conducted using PorcineSNP60 BeadChips. Single-marker and Bayesian multi-marker approaches were integrated to identify genomic regions and corresponding genes overlapping for both methods. GWAS was performed for haematological traits of 591 German Landrace pig. Heritability estimates for haematological traits were medium to high. In total 252 single SNPs associated with 12 haematological traits were identified (NegLog10 of p-value > 5). The Bayesian multi-marker approach revealed 102 QTL regions across the genome, indicated by 1-Mb windows with contribution to additive genetic variance above 0.5%. The integration of both methods resulted in 24 overlapping QTL regions. This study identified overlapping QTL regions from single- and multi-marker approaches for haematological traits. Identifying candidate genes that affect blood cell traits provides the first step towards the understanding of the molecular basis of haematological phenotypes.
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