Evidence map›Paper›PMID 27434003›Full record

ArticleNature immunology2016

A dRAStic RHOAdblock of Pyrin inflammasome activation.

Andrea Dorfleutner, Christian Stehlik

Abstract readComment
In one paragraph

Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Mevalonate kinase deficiency presenting as recurrent rectal abscesses and perianal fistulae.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018
    Article
  5. Article
  6. Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Andrea DorfleutnerDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Interdepartmental Immunobiology Center and Skin Disease Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Christian StehlikDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Interdepartmental Immunobiology Center and Skin Disease Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Regulation of cytosolic pattern recognition receptor signaling in macrophagesR01AI099009 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEHLIK, CHRISTIAN · 2013 to 2022
$4.7M
Molecular Regulation of Systemic InflammationR01AI120625 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2016 to 2020
$2.0M
A Regulatory Checkpoint in the Pathogenesis of Inflammatory ArthritisR01AR064349 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STEHLIK, CHRISTIAN · 2013 to 2017
$1.9M
Inflammasome Adaptor and Effectors in Cryopyrinopathies and Crystal ArthropathiesK01AR066739 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA · 2015 to 2019
$471k
A novel mouse model to monitor inflammasome activation in vivoR21AI120618 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2015 to 2016
$425k
NCI NIH HHS P30 CA060553NIAID NIH HHS R01 AI099009NIAID NIH HHS R01 AI120625NIAID NIH HHS R21 AI120618NIAMS NIH HHS K01 AR066739NIAMS NIH HHS R01 AR064349
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

InflammasomesPyrinCarrier ProteinsCaspase 1Interleukin-1betaCarrier ProteinsCaspase 1InflammasomesInterleukin-1betaPyrin

Identifiers

PMID27434003
PMCPMC5110454

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.