ArticlePLoS medicine2016
Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study.
Article in PLoS medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of obesity and risk of diabetic retinopathy in diabetes patients: A meta-analysis of prospective cohort studies.Medicine · 2018Pooled it
- One-Hour Post-Load Glucose Is Associated with Multisystem Complications in People Living with Obesity.Biomolecules · 2026Observational
- Adiposity in Adults and Life Expectancy with and without Cardiovascular Disease. The Doetinchem Cohort Study.Global heart · 2026Article
- The Regulator of G Protein Signaling 14 Knockout Mouse, a Model of Healthful Longevity Protects Against Obesity and Glucose Intolerance Through a Brown Adipose Tissue Mechanism.International journal of molecular sciences · 2025Article
- Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population.Diabetologia · 2024Observational
- Risk of diabetes mellitus based on the interactive association between G6PD rs72554664 polymorphism and sex in Taiwan Biobank individuals.Scientific reports · 2024Article
- Socioeconomic Status Transition Throughout Life and Risk of Dementia.JAMA network open · 2024Article
- Influence of Adipokines on Metabolic Dysfunction and Aging.Biomedicines · 2024Review
- Associations Between Mid- to Late-Life Body Mass Index and Chronic Disease-Free Survival: A Nationwide Twin Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy.Frontiers in endocrinology · 2024Review
- Healthy lifestyle and life expectancy free of major chronic diseases at age 40 in China.Nature human behaviour · 2023Article
- Mechanism of the antidiabetic action ofFrontiers in nutrition · 2023Review
- How Childhood Socioeconomic Status Impacts Adult Food Preference: The Mediating Role of Stress and Trait Appetite.Behavioral sciences (Basel, Switzerland) · 2022Article
- Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age.Age and ageing · 2022Article
- Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study.BMJ (Clinical research ed.) · 2022Article
- The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy-A Review of the Literature.Nutrients · 2022Review
- Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension.Cardiovascular diabetology · 2021Observational
- Mortality from diabetes mellitus and its impact on life expectancy at 60 years of age in Mexico.Revista de saude publica · 2021Observational
- Clinical Impact of Liraglutide as a Treatment of Obesity.Clinical pharmacology : advances and applications · 2021Review
- Trajectories of BMI Before Diagnosis of Type 2 Diabetes: The Rotterdam Study.Obesity (Silver Spring, Md.) · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverweight and obesity are associated with increased risk of type 2 diabetes. Limited evidence exists regarding the effect of excess weight on years lived with and without diabetes. We aimed to determine the association of overweight and obesity with the number of years lived with and without diabetes in a middle-aged and elderly population. METHODS AND
findingsThe study included 6,499 individuals (3,656 women) aged 55 y and older from the population-based Rotterdam Study. We developed a multistate life table to calculate life expectancy for individuals who were normal weight, overweight, and obese and the difference in years lived with and without diabetes. For life table calculations, we used prevalence, incidence rate, and hazard ratios (HRs) for three transitions (healthy to diabetes, healthy to death, and diabetes to death), stratifying by body mass index (BMI) at baseline and adjusting for confounders. During a median follow-up of 11.1 y, we observed 697 incident diabetes events and 2,192 overall deaths. Obesity was associated with an increased risk of developing diabetes (HR: 2.13 [p < 0.001] for men and 3.54 [p < 0.001] for women). Overweight and obesity were not associated with mortality in men and women with or without diabetes. Total life expectancy remained unaffected by overweight and obesity. Nevertheless, men with obesity aged 55 y and older lived 2.8 (95% CI -6.1 to -0.1) fewer y without diabetes than normal weight individuals, whereas, for women, the difference between obese and normal weight counterparts was 4.7 (95% CI -9.0 to -0.6) y. Men and women with obesity lived 2.8 (95% CI 0.6 to 6.2) and 5.3 (95% CI 1.6 to 9.3) y longer with diabetes, respectively, compared to their normal weight counterparts. Since the implications of these findings could be limited to middle-aged and older white European populations, our results need confirmation in other populations.
conclusionsObesity in the middle aged and elderly is associated with a reduction in the number of years lived free of diabetes and an increase in the number of years lived with diabetes. Those extra years lived with morbidity might place a high toll on individuals and health care systems.
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