Trial reportDepression and anxiety2016
Pathways to anxiety-depression comorbidity: A longitudinal examination of childhood anxiety disorders.
Trial report in Depression and anxiety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Eczema is a shared risk factor for anxiety and depression: A meta-analysis and systematic review.PloS one · 2022Pooled it
- Results from the Child/Adolescent Anxiety Multimodal Longitudinal Study (CAMELS): Functional outcomes.Journal of consulting and clinical psychology · 2018Trial
- Effects of the Super Skills for Life Program on Depression and Anxiety Symptoms in Children and Adolescents: A Systematic Review and Meta-Analysis.Clinical child and family psychology review · 2026Review
- Neurobehavioral Effects of Two Distinct Anti-Inflammatory Drugs in a Two-Week Chronic Stress Model in Zebrafish.Brain sciences · 2026Article
- Who's at risk for emergent depression years later? Predictive modeling in a nine-year longitudinal cohort.BMC psychiatry · 2026Article
- Network analysis of anxiety and depressive symptoms among patients with cardiovascular disease.BMC public health · 2025Article
- Network analysis of meaning in life, perceived social support, and depressive symptoms among vocational undergraduate students.Frontiers in psychiatry · 2025Article
- Mediators between Positive and Negative Parenting and Child Depressive and Anxious Symptoms: Findings from a Diverse, At-Risk Sample.Children (Basel, Switzerland) · 2022Article
- Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial.Child psychiatry and human development · 2021Article
- Changes in network centrality of psychopathology symptoms between the COVID-19 outbreak and after peak.Molecular psychiatry · 2020Article
- Association of ADHD symptoms, depression and suicidal behaviors with anxiety in Chinese medical college students.BMC psychiatry · 2020Article
- Anxiety-Depression of Dialysis Patients and Their Caregivers.Medicina (Kaunas, Lithuania) · 2019Article
- A holistic approach to factors affecting depression in haemodialysis patients.International urology and nephrology · 2018Review
- Effects of Yoga on Thalamic Gamma-Aminobutyric Acid, Mood and Depression: Analysis of Two Randomized Controlled Trials.Neuropsychiatry · 2018Article
- Long-Term Outcomes of Youth Treated for an Anxiety Disorder: A Critical Review.Clinical child and family psychology review · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAnxiety disorders are prevalent in youth and associated with later depressive disorders. A recent model posits three distinct anxiety-depression pathways. Pathway 1 represents youth with a diathesis to anxiety that increases risk for depressive disorders; Pathway 2 describes youth with a shared anxiety-depression diathesis; and Pathway 3 consists of youth with a diathesis for depression who develop anxiety as a consequence of depression impairment. This is the first partial test of this model following cognitive-behavioral treatment (CBT) for child anxiety.
methodThe present study included individuals (N = 66; M age = 27.23 years, SD = 3.54) treated with CBT for childhood anxiety disorders 7-19 years (M = 16.24; SD = 3.56) earlier. Information regarding anxiety (i.e., social phobia (SoP), separation anxiety disorder (SAD), generalized anxiety disorder (GAD)) and mood disorders (i.e., major depressive disorder (MDD) and dysthymic disorders) was obtained at pretreatment, posttreatment, and one or more follow-up intervals via interviews and self-reports.
resultsEvidence of pathways from SoP, SAD, and GAD to later depressive disorders was not observed. Treatment responders evidenced reduced GAD and SoP over time, although SoP was observed to have a more chronic and enduring pattern.
conclusionsEvidence for typically observed pathways from childhood anxiety disorders was not observed. Future research should prospectively examine if CBT treatment response disrupts commonly observed pathways.
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