ReviewNatural product reports2016
Clerodane diterpenes: sources, structures, and biological activities.
Review in Natural product reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 249 citations in OpenAlex.
- Diterpenes with Abietane and Clerodane Skeletons from the MexicanMolecules (Basel, Switzerland) · 2026Review
- Clerodane Diterpenes and Structural Modification of 12-Oxo-Hardwickiic Acid from the Roots ofACS omega · 2026Article
- Solidagoic Acids L and M: Novel AntibacterialAntibiotics (Basel, Switzerland) · 2026Article
- Antibacterial Activity of Ent-Clerodane-Type Diterpenoids and Flavonoids From the Roots of Croton pseudopulchellus Pax (Euphorbiaceae).Chemistry & biodiversity · 2026Article
- Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism.ChemistryOpen · 2026Article
- Review
- Comparative genome analysis provides a foundation for defining salvinorin A biosynthesis in Salvia divinorum.Nature communications · 2026Article
- Thermal, geological and biological processes shape the internal fabric and fluorescence of amber from La Cumbre, Dominican Republic.Scientific reports · 2026Article
- Article
- cis-Clerodane-type diterpenoids from Tinospora crispa and their anticancer potential.Archives of pharmacal research · 2026Article
- 14,15-dihydroclerodin (CScientific reports · 2025Article
- Discovery of Undescribed Clerodane Diterpenoids with Antimicrobial Activity Isolated from the Roots ofInternational journal of molecular sciences · 2025Article
- A high-quality genome assembly of the tetraploid Teucrium chamaedrys unveils a recent whole-genome duplication and a large biosynthetic gene cluster for diterpenoid metabolism.Plant communications · 2025Article
- Bioassay-Guided Isolation ofPlants (Basel, Switzerland) · 2025Article
- Three cytochrome P450 enzymes consecutively catalyze the biosynthesis of furanoclerodane precursors in Salvia species.Plant communications · 2025Article
- The plant-beneficial fungus Trichoderma harzianum T22 modulates plant metabolism and negatively affects Nezara viridula.BMC plant biology · 2025Article
- Bioavailability for the Improved Therapeutic Profile ofInternational journal of molecular sciences · 2025Article
- The Antiproliferative Activity and NO Inhibition ofMolecules (Basel, Switzerland) · 2025Article
- Diterpenes: Nature's Hidden Gems of Immunomodulation.International journal of molecular sciences · 2025Review
- Exploring Therapeutic Frontiers: Unveiling the Potential of Natural Diterpenoid Derivatives in Addressing Neurological Disorders.Current pharmaceutical biotechnology · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 3 countries.
Funding
Abstract
Covering: 1990 to 2015The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.