Evidence map›Paper›PMID 27433488›Full record

ArticleInternational scholarly research notices2014

Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents.

Cheril L Clarson, Hilary K Brown, Stefanie De Jesus, Michelle Jackman, Farid H Mahmud, Harry Prapavessis, Tracy Robinson, J Kevin Shoemaker, Margaret Watson, A Justine Dowd and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International scholarly research notices, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00934570. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00934570 phase4completed

Reduction of Adolescent Risk Factors for Type 2 Diabetes and Cardiovascular Disease

Ran2009Enrolled60Registered outcomes2Posted comparisons0ConditionsObesity, Type 2 DiabetesArmsIntensive exercise, Metformin and standard exercise, Metformin Intensive exercise, Placebo Standard exercise
Open the trial in the graph
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. A Systemic Review of Pharmacological Management of Pediatric Obesity.Journal of pharmacy & bioallied sciences · 2025
    Review
  5. Review
  6. Article
  7. Effects of metformin in obesity treatment in different populations: a meta-analysis.Therapeutic advances in endocrinology and metabolism · 2020 · on this map
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cheril L ClarsonChildren's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9; Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5.
Hilary K BrownDepartment of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada N6A 5A5.
Stefanie De JesusSchool of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
Michelle JackmanChildren's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.
Farid H MahmudChildren's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.
Harry PrapavessisSchool of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.ORCID 0000-0003-0636-7316
Tracy RobinsonChildren's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.ORCID 0000-0001-5755-9452
J Kevin ShoemakerSchool of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
Margaret WatsonChildren's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.ORCID 0000-0003-2948-5788
A Justine DowdSchool of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
David J HillLawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. To assess a comprehensive, intensive lifestyle intervention in combination with metformin extended release (MXR) or placebo on body mass index (BMI) and risk factors for type 2 diabetes and cardiovascular disease in obese adolescents. Study Design. Sixty-nineobese adolescents (mean BMI 32.5) received a comprehensive lifestyle intervention with structured dietary, physical activity, and behavioral components for 24 months. Subjects were randomized to 1 of 4 groups: MXR (33) 2,000 mg daily or placebo, with either moderate or vigorous intensity exercise for the first 3 months. Subsequently the exercise intervention was the same for all 4 groups. Results. Anthropometry measurements did not differ with initial exercise intensity at any time. At 3 months % body fat decreased in all 4 groups (P < 0.006). BMI and % body fat decreased in the MXR groups, but not the placebo groups, at 6 (-0.88, -3.16) and 12 months (-0.56, -2.34) (P < 0.05). Insulin resistance, fasting blood glucose, and leptin improved in all groups at 6 and 12 months. A high subject attrition rate (58%) occurred by 24 months. Conclusion. A comprehensive, intensive lifestyle intervention combined with MXR led to a decline in BMI and % body fat at 1 year independent of initial exercise intensity. This trial is registered with ClinicalTrials.gov NCT00934570 .

Identifiers

PMID27433488
PMCPMC4897295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.