ArticleAnnals of surgical treatment and research2016
Necrotizing soft tissue infection: analysis of the factors related to mortality in 30 cases of a single institution for 5 years.
Article in Annals of surgical treatment and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05529628 (The Cytokines and Immune Checkpoint Differences Between Fournier Gangrene and Perianal Abscess), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Cytokines and Immune Checkpoint Differences Between Fournier Gangrene and Perianal Abscess
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2020Pooled it
- Predicting limb amputation in trauma-related necrotizing fasciitis of the extremities: insights from a 10-year cohort.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Necrotizing Skin and Soft Tissue Infections Admitted to Intensive Care Unit in Reunion Island: A Retrospective Cohort Study.The American journal of tropical medicine and hygiene · 2021Article
- Necrotizing soft tissue infection: clinical characteristics, diagnosis, and management of 32 cases in Beijing.The Journal of international medical research · 2021Article
- Medicolegal implications from litigations involving necrotizing fasciitis.Annals of surgical treatment and research · 2020Article
- Determinants of Mortality in Necrotizing Soft Tissue Infections.Hellenike cheirourgike. Acta chirurgica Hellenica · 2020Article
- Analysis of prognostic factors affecting poor outcomes in 41 cases of Fournier gangrene.Annals of surgical treatment and research · 2018Article
- Fournier's Gangrene: Literature Review and Clinical Cases.Urologia internationalis · 2018Review
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNecrotizing soft tissue infection is the infection of the soft tissue with necrotic changes. It is rare, but results in high mortality. We analyzed the characteristics of patients, prognosis, and mortality factors after reviewing 30 cases of a single hospital for 5 years.
methodsFrom January 2009 to December 2013, 30 patients diagnosed with necrotizing fasciitis or Fournier's gangrene in Pusan National University Hospital were enrolled for this study. The following parameters were analyzed retrospectively: demographics, infection site, initial laboratory finding, initial antibiotics, isolated microorganisms, number of surgeries, time to first operation, length of intensive care unit, and total hospital stays.
resultsThe overall mortality rate was 23.3%. Mean body mass index (BMI) of the survival group (24.7 ± 5.0 kg/m(2)) was significantly higher than the nonsurvival group (22.0 ± 1.4 kg/m(2), P = 0.029). When BMI was less than 23 kg/m(2), the mortality rate was significantly higher (P = 0.025). Two patients (6.7%) with chronic kidney disease requiring hemodialysis died (P = 0.048). Initial WBC count (>13×10(3)/µL), CRP (>26.5 mg/dL), and platelet (PLT) count (<148×10(3)/µL) were found to have negative impact on the prognosis of necrotizing soft tissue infection. Factors such as potassium level, blood urea nitrogen (>27.6 mg/dL), serum creatinine (>1.2 mg/dL) that reflected kidney function were significant mortality factors.
conclusionPatients with low BMI or abnormal values of WBC count, CRP, and PLT count reflecting the degree of infection or abnormal renal function will need more intensive care.
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