Evidence map›Paper›PMID 27433433›Full record

ReviewGlobal spine journal2016

A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer.

Daniel M Sciubba, C Rory Goodwin, Alp Yurter, Derek Ju, Ziya L Gokaslan, Charles Fisher, Laurence D Rhines, Michael G Fehlings, Daryl R Fourney, Ehud Mendel and 9 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Global spine journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 3 countries.

Daniel M SciubbaDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
C Rory GoodwinDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Alp YurterDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Derek JuDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Ziya L GokaslanDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Charles FisherDivision of Spine, Department of Orthopaedics, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada.
Laurence D RhinesDepartment of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Michael G FehlingsDivision of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
Daryl R FourneyDivision of Neurosurgery, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Ehud MendelDepartment of Neurological Surgery, The James Comprehensive Cancer Center and The Wexner Medical Center at the Ohio State University, Columbus, Ohio, United States.
Ilya LauferDepartment of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States.
Chetan BettegowdaDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Shreyaskumar R PatelSarcoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Y Raja RampersaudDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Jeremy ReynoldsSpinal Division, Oxford University Hospital NHS Trust, Oxford, United Kingdom.
Dean ChouDepartment of Neurological Surgery, University of California San Francisco, San Francisco, California, United States.
Michael H WeberDivision of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada.
Michelle J ClarkeDepartment of Neurosurgery, Mayo Clinic, Rochester, Minnesota, United States.
Johns Hopkins Medicine · USJohns Hopkins University · USNeurological Surgery · USThe University of Texas MD Anderson Cancer Center · USUniversity of Toronto · CAMayo Clinic · USMcGill University · CAOxford University Hospitals NHS Trust · GBSunnybrook Health Science Centre · CAUniversity of British Columbia · CAUniversity of California, San Francisco · USUniversity of Saskatchewan · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

STUDY

designReview of the literature.

objectiveSurgery and cement augmentation procedures are effective palliative treatment of symptomatic spinal metastases. Our objective is to systematically review the literature to describe the survival, prognostic factors, and clinical outcomes of surgery and cement augmentation procedures for breast cancer metastases to the spine.

methodsWe performed a literature review using PubMed to identify articles that reported outcomes and/or prognostic factors of the breast cancer patient population with spinal metastases treated with any surgical technique since 1990.

resultsThe median postoperative survival for metastatic breast cancer was 21.7 months (8.2 to 36 months), the mean rate of any pain improvement was 92.9% (76 to 100%), the mean rate of neurologic improvement was 63.8% (53 to 100%), the mean rate of neurologic decline was 4.1% (0 to 8%), and the local tumor control rate was 92.6% (89 to 100%). Kyphoplasty studies reported a high rate of pain control in selected patients. Negative prognostic variables included hormonal (estrogen and progesterone) and human epidermal growth factor receptor 2 (HER2) receptor refractory tumor status, high degree of axillary lymph node involvement, and short disease-free interval (DFI). All other clinical or prognostic parameters were of low or insufficient strength.

conclusionWith respect to clinical outcomes, surgery consistently yielded neurologic improvements in patients presenting with a deficit with a minimal risk of worsening; however, negative prognostic factors associated with shorter survival following surgery include estrogen receptor/progesterone receptor negativity, HER2 negativity, and a short DFI.

Indexed as

breast cancerkyphoplastymetastasisspinesurgerysurvivaltumorvertebroplasty

Identifiers

PMID27433433
PMCPMC4947406
OpenAlexW2292459862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.