ArticleCureus2016
Manual Planimetry of the Medial Temporal Lobe Versus Automated Volumetry of the Hippocampus in the Diagnosis of Alzheimer's Disease.
Article in Cureus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predicting progression to dementia with "comprehensive visual rating scale" and machine learning algorithms.Frontiers in neurology · 2022Article
- Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease.Annals of geriatric medicine and research · 2021Article
- Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer's Disease Patients.BioMed research international · 2020Article
- AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks.NeuroImage. Clinical · 2019Article
- Subjective Cognitive Decline Is Associated with Greater White Matter Hyperintensity Volume.Journal of Alzheimer's disease : JAD · 2018Article
- A 'Comprehensive Visual Rating Scale' for predicting progression to dementia in patients with mild cognitive impairment.PloS one · 2018Article
- Imaging Biomarkers in Alzheimer's Disease: A Practical Guide for Clinicians.Journal of Alzheimer's disease reports · 2017Review
- The anteroposterior and primary-to-posterior limbic ratios as MRI-derived volumetric markers of Alzheimer's disease.Journal of the neurological sciences · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThough a disproportionate rate of atrophy in the medial temporal lobe (MTA) represents a reliable marker of Alzheimer's disease (AD) pathology, measurement of the MTA is not currently widely used in daily clinical practice. This is mainly because the methods available to date are sophisticated and difficult to implement in clinical practice (volumetric methods), are poorly explored (linear and planimetric methods), or lack objectivity (visual rating). Here, we aimed to compare the results of a manual planimetric measure (the yearly rate of absolute atrophy of the medial temporal lobe, 2D-yrA-MTL) with the results of an automated volumetric measure (the yearly rate of atrophy of the hippocampus, 3D-yrA-H).
methodsA series of 1.5T MRI studies on 290 subjects in the age range of 65-85 years, including patients with AD (n = 100), mild cognitive impairment (MCI) (n = 100), and matched controls (n = 90) from the AddNeuroMed study, were examined by two independent subgroups of researchers: one in charge of volumetric measures and the other in charge of planimetric measures.
resultsThe means of both methods were significantly different between AD and the other two diagnostic groups. In the differential diagnosis of AD against controls, 3D-yrA-H performed significantly better than 2D-yrA-MTL while differences were not statistically significant in the differential diagnosis of AD against MCI.
conclusionAutomated volumetry of the hippocampus is superior to manual planimetry of the MTL in the diagnosis of AD. Nevertheless, the 2D-yrAMTL is a simpler method that could be easily implemented in clinical practice when volumetry is not available.
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