ArticleJournal of gastric cancer2016
Clinicopathological Significance of Elevated PIK3CA Expression in Gastric Cancer.
Article in Journal of gastric cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Natural History and Genomic Landscape of Chemotherapy-Resistant Muscle-Invasive Bladder Cancer.JCO precision oncology · 2024Article
- The viral etiology of EBV-associated gastric cancers contributes to their unique pathology, clinical outcomes, treatment responses and immune landscape.Frontiers in immunology · 2024Review
- Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor.Animals : an open access journal from MDPI · 2021Article
- Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric CancerFrontiers in oncology · 2021Article
- Genetic profiling of somatic alterations by Oncomine Focus Assay in Korean patients with advanced gastric cancer.Oncology letters · 2020Article
- UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling.Journal of experimental & clinical cancer research : CR · 2019Article
- MicroRNA-related transcription factor regulatory networks in human colorectal cancer.Medicine · 2019Article
- Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma.Molecular medicine reports · 2019Article
- LOXL1-AS1 Drives The Progression Of Gastric Cancer Via Regulating miR-142-5p/PIK3CA Axis.OncoTargets and therapy · 2019Article
- Association between PIK3CA alteration and prognosis of gastric cancer patients: a meta-analysis.Oncotarget · 2018Article
- Progression inference for somatic mutations in cancer.Heliyon · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated PIK3CA expression in gastric cancer and explored the relationships between the PIK3CA expression level and clinicopathological features as well as survival of the patients. MATERIALS AND
methodsWe examined PIK3CA expression in a tissue microarray of 178 gastric adenocarcinomas by immunohisto-chemistry and reviewed patients' medical records.
resultsIn our study, 112 of the 178 gastric cancer patients displayed positive PIK3CA expression. Overexpression of PIK3CA was correlated with low grade differentiation (P=0.001), frequent lymphatic invasion (P=0.032), and high T stage (P=0.040). Patients with positive PIK3CA staining were more likely to display worse overall survival rate than those with negative PIK3CA staining, as determined by Kaplan-Meier survival analysis with log-rank test (P=0.047) and a univariate analysis using the Cox proportional hazard model (hazard ratio=1.832, P=0.051).
conclusionsElevated PIK3CA expression was significantly correlated with tumor invasiveness, tumor phenotypes, and poor patient survival.
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