Evidence map›Paper›PMID 27433356›Full record

Trial reportJournal of obesity2016

Race or Resource? BMI, Race, and Other Social Factors as Risk Factors for Interlimb Differences among Overweight Breast Cancer Survivors with Lymphedema.

Lorraine T Dean, Anagha Kumar, Taehoon Kim, Matthew Herling, Justin C Brown, Zi Zhang, Margaret Evangelisti, Renata Hackley, Jiyoung Kim, Andrea Cheville and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of obesity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Lymphatic Pain in Breast Cancer Survivors.Lymphatic research and biology · 2022
    Article
  8. Article
  9. Observational
  10. Drivers of cost differences between US breast cancer survivors with or without lymphedema.Journal of cancer survivorship : research and practice · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Lorraine T DeanJohns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-2272-2755
Anagha KumarMedStar Health Research Institute and MedStar Georgetown University Hospital, Division of Biostatistics, Washington, DC 20007, USA.
Taehoon KimSchool of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew HerlingThe Wharton School of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Justin C BrownPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zi ZhangJohns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Margaret EvangelistiPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Renata HackleyRecruitment, Outcomes, and Assessment Resource Core, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jiyoung KimSchool of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
Andrea ChevilleThe Mayo Clinic, Department of Physical Medicine and Rehabilitation, Rochester, MN 55905, USA.
Andrea B TroxelPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
J Sanford SchwartzPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kathryn H SchmitzPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
University of Pennsylvania · USJohns Hopkins University · USGeorgetown University · USMayo Clinic in Arizona · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
The Women In Steady Exercise Research (WISER) SurwVor TrialU54CA155850 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHMITZ, KATHRYN H. · 2011 to 2015
$9.1M
Social Determinants of Breast Cancer SurvivorshipK01CA184288 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DEAN, LORRAINE TIERA · 2014 to 2018
$767k
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR001409NCI NIH HHS K01 CA184288NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA016520NCI NIH HHS U54 CA155850
6 · The paper itself

Abstract

Introduction. High BMI is a risk factor for upper body breast cancer-related lymphedema (BCRL) onset. Black cancer survivors are more likely to have high BMI than White cancer survivors. While observational analyses suggest up to 2.2 times increased risk of BCRL onset for Black breast cancer survivors, no studies have explored race or other social factors that may affect BCRL severity, operationalized by interlimb volume difference (ILD). Materials and Methods. ILD was measured by perometry for 296 overweight (25 > BMI < 50) Black (n = 102) or White (n = 194) breast cancer survivors (>6 months from treatment) in the WISER Survivor trial. Multivariable linear regression examined associations between social and physical factors and ILD. Results. Neither Black race (-0.26, p = 0.89) nor BMI (0.22, p = 0.10) was associated with ILD. Attending college (-4.89, p = 0.03) was the strongest factor associated with ILD, followed by having more lymph nodes removed (4.75, p = 0.01), >25% BCRL care adherence (4.10, p = 0.01), and years since treatment (0.55, p < 0.001). Discussion. Neither race nor BMI was associated with ILD among overweight cancer survivors. Education, a proxy for resource level, was the strongest factor associated with greater ILD. Tailoring physical activity and weight loss interventions designed to address BCRL severity by resource rather than race should be considered.

Indexed as

Breast NeoplasmsArmBody Mass IndexEthnicityFemaleHumansLymphedemaMaleMiddle AgedObesityRisk FactorsSocioeconomic FactorsSurvivors

Identifiers

PMID27433356
PMCPMC4940553
OpenAlexW2468166610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.