ArticleTropical medicine and health2016
Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings.
Article in Tropical medicine and health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum.Analytical and bioanalytical chemistry · 2022Article
- Development and application of immunoassays for rapid quality control of the antimalarial drug combination artesunate-mefloquine.Journal of pharmaceutical and biomedical analysis · 2022Article
- Laboratory evaluation of twelve portable devices for medicine quality screening.PLoS neglected tropical diseases · 2021Article
- Development of monoclonal antibody-based immunoassays for quantification and rapid assessment of dihydroartemisinin contents in antimalarial drugs.Journal of pharmaceutical and biomedical analysis · 2018Article
- Field detection devices for screening the quality of medicines: a systematic review.BMJ global health · 2018Article
- Quality Testing of Artemisinin-Based Antimalarial Drugs in Myanmar.The American journal of tropical medicine and hygiene · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundGood-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases.
methodsTo develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin drugs for resource-limited areas, we used specific monoclonal antibodies against artesunate and artemether, and developed prototypes of lateral flow dipstick assays. In this pilot test, we evaluated the feasibility of these dipsticks under different endemic settings and their performance in the hands of untrained personnel.
resultsThe results showed that the dipstick tests can be successfully performed by different investigators with the included instruction sheet. None of the artemether and artesunate drugs collected from public pharmacies in different endemic countries failed the test.
conclusionIt is possible that the simple dipstick assays, with future optimization of test conditions and sensitivity, can be used as a qualitative and semi-quantitative assay for rapid screening of counterfeit artemisinin drugs in endemic settings.
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