ArticleProceedings of the National Academy of Sciences of the United States of America2016
Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 196 citations in OpenAlex.
- High-throughput screening and structure-guided design of small molecules enable modulation of SAL-PAP stress signaling.Journal of experimental botany · 2026Article
- Sulfur metabolism-dependent retrograde signaling for oxidative stress acclimation.Journal of experimental botany · 2026Review
- Engineering plant stress responses to combat climate change.The New phytologist · 2026Article
- Modulation of SAL retrograde signalling promotes yield and water productivity responses in dynamic field environments.The New phytologist · 2026Article
- Chloroplast Fibrillin-Mediated α-Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Posttranslational Modifications in Proteins Under Stress and Memory.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Multiplex CRISPR/Cas9-mediated genome editing to address drought tolerance in wheat.GM crops & food · 2025Article
- Implication ofInternational journal of molecular sciences · 2025Article
- Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling.Plant, cell & environment · 2025Review
- Effect of Singlet Oxygen on the Stomatal and Cell Wall of Rice Seedling Under Different Stresses.International journal of molecular sciences · 2025Article
- Metabolism in Sync: The Circadian Clock, a Central Hub for Light-Driven Chloroplastic and Mitochondrial Entrainment.Plants (Basel, Switzerland) · 2025Review
- Transcript profiling of plastid ferrochelatase two mutants reveals that chloroplast singlet oxygen signals lead to global changes in RNA profiles and are mediated by Plant U-Box 4.BMC plant biology · 2025Article
- SAL1-PAP retrograde signaling orchestrates photosynthetic and extracellular reactive oxygen species for stress responses.The Plant journal : for cell and molecular biology · 2025Article
- Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- 1',4'-trans-diol-ABA enhances the growth and physiological characteristics of rice (Oryza sativa L.) seedlings under salt stress.PloS one · 2025Article
- Antioxidant Responses and Redox Regulation Within Plant-Beneficial Microbe Interaction.Antioxidants (Basel, Switzerland) · 2024Review
- Efficient gene editing of a model fern species through gametophyte-based transformation.Plant physiology · 2024Article
- ROS as Signaling Molecules to Initiate the Process of Plant Acclimatization to Abiotic Stress.International journal of molecular sciences · 2024Review
- Post-Translational Modifications to Cysteine Residues in Plant Proteins and Their Impact on the Regulation of Metabolism and Signal Transduction.International journal of molecular sciences · 2024Review
- Phosphorylated transcription factor PuHB40 mediates ROS-dependent anthocyanin biosynthesis in pear exposed to high light.The Plant cell · 2024Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Intracellular signaling during oxidative stress is complex, with organelle-to-nucleus retrograde communication pathways ill-defined or incomplete. Here we identify the 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress sensor in plant chloroplasts. Arabidopsis thaliana SAL1 (AtSAL1) senses changes in photosynthetic redox poise, hydrogen peroxide, and superoxide concentrations in chloroplasts via redox regulatory mechanisms. AtSAL1 phosphatase activity is suppressed by dimerization, intramolecular disulfide formation, and glutathionylation, allowing accumulation of its substrate, PAP, a chloroplast stress retrograde signal that regulates expression of plastid redox associated nuclear genes (PRANGs). This redox regulation of SAL1 for activation of chloroplast signaling is conserved in the plant kingdom, and the plant protein has evolved enhanced redox sensitivity compared with its yeast ortholog. Our results indicate that in addition to sulfur metabolism, SAL1 orthologs have evolved secondary functions in oxidative stress sensing in the plant kingdom.
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