ArticleThe Journal of experimental medicine2016
TNF activation of NF-κB is essential for development of single-positive thymocytes.
Article in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- NF-κB in inflammation and cancer.Cellular & molecular immunology · 2025Review
- Article
- NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells.Cell death and differentiation · 2025Article
- Single-cell multiomic analysis of thymocyte development reveals drivers of CD4Nature immunology · 2023Article
- Single-cell transcriptome landscape and antigen receptor dynamic during SARS-CoV-2 vaccination.Genes & diseases · 2023Article
- Severe CD8+ T Lymphopenia in WHIM Syndrome Caused by Selective Sequestration in Primary Immune Organs.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Double knockin mice show NF-κB trajectories in immune signaling and aging.Cell reports · 2022Article
- Mapping the developing human immune system across organs.Science (New York, N.Y.) · 2022Article
- Article
- Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses.Biomedicines · 2022Article
- The dichotomous outcomes of TNFα signaling in CD4Frontiers in immunology · 2022Review
- Mice transgenic for humanOncoimmunology · 2022Article
- Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells.Frontiers in immunology · 2022Article
- The thymus medulla and its control of αβT cell development.Seminars in immunopathology · 2021Review
- Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus.Blood advances · 2021Article
- Self-enforcing HMGB1/NF-κB/HIF-1α Feedback Loop Promotes Cisplatin Resistance in Hepatocellular Carcinoma Cells.Journal of Cancer · 2020Article
- Fold-Change Detection of NF-κB at Target Genes with Different Transcript Outputs.Biophysical journal · 2019Article
- Article
- Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways.PloS one · 2019Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
NF-κB activation has been implicated at multiple stages of thymic development of T cells, during which it is thought to mediate developmental signals originating from the T cell receptor (TCR). However, the Card11-Bcl10-Malt1 (CBM) complex that is essential for TCR activation of NF-κB in peripheral T cells is not required for thymocyte development. It has remained unclear whether the TCR activates NF-κB independent of the CBM complex in thymocyte development or whether another NF-κB activating receptor is involved. In the present study, we generated mice in which T cells lacked expression of both catalytic subunits of the inhibitor of κB kinase (IKK) complex, IKK1 and IKK2, to investigate this question. Although early stages of T cell development were unperturbed, maturation of CD4 and CD8 single-positive (SP) thymocytes was blocked in mice lacking IKK1/2 in the T cell lineage. We found that IKK1/2-deficient thymocytes were specifically sensitized to TNF-induced cell death in vitro. Furthermore, the block in thymocyte development in IKK1/2-deficient mice could be rescued by blocking TNF with anti-TNF mAb or by ablation of TNFRI expression. These experiments reveal an essential role for TNF activation of NF-κB to promote the survival and development of single positive T cells in the thymus.
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