ArticleHypertension (Dallas, Tex. : 1979)2016
Trends in Antihypertensive Medication Discontinuation and Low Adherence Among Medicare Beneficiaries Initiating Treatment From 2007 to 2012.
Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adherence to antihypertensives in the United States: A comparative meta-analysis of 23 million patients.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.Journal of the American Heart Association · 2022Pooled it
- Analysis of Therapeutic Inertia and Race and Ethnicity in the Systolic Blood Pressure Intervention Trial: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Sustained blood pressure control and coronary heart disease, stroke, heart failure, and mortality: An observational analysis of ALLHAT.Journal of clinical hypertension (Greenwich, Conn.) · 2019Trial
- A successful intervention to improve medication adherence in Black patients with hypertension: Mediation analysis of 28-site TEAM trial.Journal of the American Pharmacists Association : JAPhATrial
- Fixed-Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Association Between Antihypertensive Treatment Discontinuation and the Development of Intracerebral Hemorrhage in Japanese Patients With Hypertension: The LIFE Study.Journal of the American Heart Association · 2025Article
- Trends and Predictors of Antihypertensive Medication Adherence in Commercially Insured Adults under 65 (2018-2023).Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Pharmacy Subscription Program and Medication Refills, Days' Supply, and Out-of-Pocket Costs.JAMA network open · 2025Article
- Effectiveness of a Knowledge Level of Hypertension on Blood Pressure Control, Treatment Adherence, and Physical Activity of Hypertensive Individuals.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Hypertension Medication and Medicare Beneficiaries: Prescription Drug Coverage Satisfaction and Medication Non-Adherence among Older Adults.Healthcare (Basel, Switzerland) · 2024Article
- The impact of clinical inertia on uncontrolled blood pressure in treated hypertension: real-world, longitudinal data from Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Association Between Self-Reported Medication Adherence and Therapeutic Inertia in Hypertension: A Secondary Analysis of SPRINT (Systolic Blood Pressure Intervention Trial).Journal of the American Heart Association · 2024Article
- Patient-Reported Reasons for Antihypertensive Medication Change: A Quantitative Study Using Social Media.Drug safety · 2024Article
- Article
- Gender-Related Factors in Medication Adherence for Metabolic and Cardiovascular Health.Metabolites · 2023Review
- New Users of Angiotensin II Receptor Blocker-Versus Angiotensin-Converting Enzyme Inhibitor-Based Antihypertensive Medication Regimens and Cardiovascular Disease Events: A Secondary Analysis of ACCORD-BP and SPRINT.Journal of the American Heart Association · 2023Article
- Association of uncontrolled blood pressure in apparent treatment-resistant hypertension with increased risk of major adverse cardiovascular events plus.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Discontinuation of Renin-Angiotensin System Inhibitors During the Early Stage of the COVID-19 Pandemic.American journal of hypertension · 2023Article
- Medication non-adherence and therapeutic inertia independently contribute to poor disease control for cardiometabolic diseases.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Low antihypertensive medication adherence is common. During recent years, the impact of low medication adherence on increased morbidity and healthcare costs has become more recognized, leading to interventions aimed at improving adherence. We analyzed a 5% sample of Medicare beneficiaries initiating antihypertensive medication between 2007 and 2012 to assess whether reductions occurred in discontinuation and low adherence. Discontinuation was defined as having no days of antihypertensive medication supply for the final 90 days of the 365 days after initiation. Low adherence was defined as having a proportion of days covered <80% during the 365 days after initiation among beneficiaries who did not discontinue treatment. Between 2007 and 2012, 41 135 Medicare beneficiaries in the 5% sample initiated antihypertensive medication. Discontinuation was stable during the study period (21.0% in 2007 and 21.3% in 2012; P-trend=0.451). Low adherence decreased from 37.4% in 2007 to 31.7% in 2012 (P-trend<0.001). After multivariable adjustment, the relative risk of low adherence for beneficiaries initiating treatment in 2012 versus in 2007 was 0.88 (95% confidence interval, 0.83-0.92). Low adherence was more common among racial/ethnic minorities, beneficiaries with Medicaid buy-in (an indicator of low income), and those with polypharmacy, and was less common among females, beneficiaries initiating antihypertensive medication with multiple classes or a 90-day prescription fill, with dementia, a history of stroke, and those who reached the Medicare Part D coverage gap in the previous year. In conclusion, low adherence to antihypertensive medication has decreased among Medicare beneficiaries; however, rates of discontinuation and low adherence remain high.
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