Evidence map›Paper›PMID 27432862›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Regional Fat Distribution and Blood Pressure Level and Variability: The Dallas Heart Study.

Yuichiro Yano, Wanpen Vongpatanasin, Colby Ayers, Aslan Turer, Alvin Chandra, Mercedes R Carnethon, Philip Greenland, James A de Lemos, Ian J Neeland

Open access · bronzeAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuichiro YanoFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Wanpen VongpatanasinFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Colby AyersFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Aslan TurerFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Alvin ChandraFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Mercedes R CarnethonFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Philip GreenlandFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
James A de LemosFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.).
Ian J NeelandFrom the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y., M.R.C., P.G.); Cardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (W.V., A.T., A.C., J.A.d.L., I.J.N.); Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas (C.A.). ian.neeland@utsouthwestern.edu.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Visceral Adiposity and Diabetes: Translating Form to Function Using ImagingK23DK106520 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI NEELAND, IAN JASON · 2015 to 2019
$776k
NCATS NIH HHS UL1 TR001105NCATS NIH HHS UL1 TR001422NIDDK NIH HHS K23 DK106520
6 · The paper itself

Abstract

Our aim was to investigate the associations of regional fat distribution with home and office blood pressure (BP) levels and variability. Participants in the Dallas Heart Study, a multiethnic cohort, underwent 5 BP measurements on 3 occasions during 5 months (2 in home and 1 in office) and quantification of visceral adipose tissue, abdominal subcutaneous adipose tissue, and liver fat by magnetic resonance imaging, and lower body subcutaneous fat by dual x-ray absorptiometry. The relation of regional adiposity with short-term (within-visit) and long-term (overall visits) mean BP and average real variability was assessed with multivariable linear regression. We have included 2595 participants with a mean age of 44 years (54% women; 48% black), and mean body mass index was 29 kg/m(2) Mean systolic BP/diastolic BP was 127/79 mm Hg and average real variability systolic BP was 9.8 mm Hg during 3 visits. In multivariable-adjusted models, higher amount of visceral adipose tissue was associated with higher short-term (both home and office) and long-term mean systolic BP (β[SE]: 1.9[0.5], 2.7[0.5], and 2.1[0.5], respectively; all P<0.001) and with lower long-term average real variability systolic BP (β[SE]: -0.5[0.2]; P<0.05). In contrast, lower body fat was associated with lower short-term home and long-term mean BP (β[SE]: -0.30[0.13] and -0.24[0.1], respectively; both P<0.05). Neither subcutaneous adipose tissue or liver fat was associated with BP levels or variability. In conclusion, excess visceral fat was associated with persistently higher short- and long-term mean BP levels and with lower long-term BP variability, whereas lower body fat was associated with lower short- and long-term mean BP. Persistently elevated BP, coupled with lower variability, may partially explain increased risk for cardiac hypertrophy and failure related to visceral adiposity.

Indexed as

AdultAge FactorsBlood Pressure Monitoring, AmbulatoryBody Fat DistributionBody Mass IndexCardiovascular DiseasesCohort StudiesComorbidityDisease ProgressionFemaleHumansHypertensionIntra-Abdominal FatLinear ModelsMaleMiddle Agedadipokineadiponectin blood pressure hypertension intra-abdominal fat obesity visceral adipose tissue

Identifiers

PMID27432862
PMCPMC4982814
OpenAlexW2499544504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.