Evidence map›Paper›PMID 27432860›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult Hypertension: The Bogalusa Heart Study.

Tao Zhang, Huijie Zhang, Ying Li, Dianjianyi Sun, Shengxu Li, Camilo Fernandez, Lu Qi, Emily Harville, Lydia Bazzano, Jiang He and 2 more

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005129 active not recruitingnot on this map

The Bogalusa Heart Study

TypeobservationalSponsorTulane UniversityRan1973 to 2029Enrolled11,737ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  8. Temporal relationship between arterial stiffness and blood pressure variability and joint effect on cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Tao ZhangFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Huijie ZhangFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Ying LiFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Dianjianyi SunFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Shengxu LiFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Camilo FernandezFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Lu QiFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Emily HarvilleFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Lydia BazzanoFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Jiang HeFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.).
Fuzhong XueFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.). wchen1@tulane.edu xuefzh@sdu.edu.cn.
Wei ChenFrom the Department of Biostatistics, School of Public Health, Shandong University, Jinan, China (T.Z., F.X.); Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA (T.Z., H.Z., Y.L., D.S., S.L., C.F., L.Q., E.H., L.B., J.H., W.C.); Department of Endocrinology and Metabolism, the First Hospital of Xiamen, Xiamen University, China (H.Z.); and Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China (Y.L.). wchen1@tulane.edu xuefzh@sdu.edu.cn.
First Affiliated Hospital of Xiamen University · CNShandong University · CN

Funding

EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)K12HD043451 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI KROUSEL-WOOD, MARIE · 2002 to 2023
$9.9M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
Childhood Secondhand Smoke and Longitudinal Cardiovascular Risk ProfileR01ES021724 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2012 to 2014
$1.8M
NIA NIH HHS R01 AG016592NIA NIH HHS RF1 AG041200NICHD NIH HHS K12 HD043451NIEHS NIH HHS R01 ES021724
6 · The paper itself

Abstract

Although obesity and insulin resistance are closely correlated, their temporal sequences in early life and influence on adult hypertension are largely unknown. This study aims to delineate the temporal relationship patterns between body mass index (BMI) and insulin in childhood and their impact on adult hypertension. The longitudinal cohort consisted of 990 adults (630 whites and 360 blacks) who had BMI and fasting insulin measured twice 5.4 years apart in childhood (mean age, 10.5 years at baseline and 15.9 years at follow-up) and blood pressure measured 14.7 years later in adulthood (mean age, 30.5 years). Cross-lagged panel and mediation analysis models were used to examine the temporal relationship between childhood BMI and insulin and its impact on adult hypertension. After adjusting for age, race, sex, and follow-up years, the cross-lagged path coefficient (β=0.33; P<0.001) from baseline BMI to follow-up insulin was significantly greater than the path coefficient (β=-0.02; P>0.05) from baseline insulin to follow-up BMI in childhood with P<0.001 for the difference in βs. Blacks and whites showed similar patterns of the temporal relationship. The path coefficient (β=0.59; P<0.001) from BMI to insulin in the hypertensive group was significantly greater than that (β=0.24; P<0.001) in normotensive group, with P<0.001 for the difference in βs between these 2 groups. The mediation effect of childhood insulin on the childhood BMI-adult hypertension association was estimated at 21.1% (P<0.001). These findings provide evidence that higher BMI levels precede hyperinsulinemia during childhood, and this 1-directional relation plays a role in the development of hypertension.

Indexed as

Body Mass IndexAdolescentAdultAge FactorsBlack or African AmericanBlack PeopleBlood Pressure DeterminationChildCohort StudiesFemaleHumansHyperinsulinismHypertensionIncidenceInsulin ResistanceLongitudinal Studiesblood pressurebody mass indexhyperinsulinismhypertensionobesity

Identifiers

PMID27432860
PMCPMC4982798
OpenAlexW2495604121

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.