ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Tract-specific white matter hyperintensities disrupt neural network function in Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
- Strategic locations of white matter hyperintensities associated with cognitive impairment across the cognitive spectrum among rural older adults: a population-based study.Alzheimer's research & therapy · 2026Article
- Damage to white matter networks resulting from small vessel disease and the effects on cognitive function.Scientific reports · 2025Article
- White matter dysfunction in Alzheimer's disease is associated with disease-related transcriptomic signatures.Communications biology · 2025Article
- Tract-Specific White Matter Hyperintensities Disrupt Brain Networks and Associated With Cognitive Impairment in Mild Traumatic Brain Injury.Human brain mapping · 2024Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Subthreshold amyloid deposition, cerebral small vessel disease, and functional brain network disruption in delayed cognitive decline after stroke.Frontiers in aging neuroscience · 2024Article
- Metabolic Messengers: ketone bodies.Nature metabolism · 2023Review
- White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways.Brain and behavior · 2023Article
- Is coronary artery calcium an independent risk factor for white matter hyperintensity?BMC neurology · 2023Article
- Spatial-temporal patterns of brain disconnectome in Alzheimer's disease.Human brain mapping · 2023Article
- Joint connectivity matrix independent component analysis: Auto-linking of structural and functional connectivities.Human brain mapping · 2023Article
- Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration.Nature metabolism · 2023Article
- Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach.Scientific reports · 2022Article
- Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination.Molecular neurodegeneration · 2022Article
- White matter hyperintensities in dementia with Lewy bodies are associated with poorer cognitive function and higher dementia stages.Frontiers in aging neuroscience · 2022Article
- Impact of regional white matter hyperintensities on specific gait function in Alzheimer's disease and mild cognitive impairment.Journal of cachexia, sarcopenia and muscle · 2021Article
- Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease.Neuron · 2021Article
- Extreme capsule is a bottleneck for ventral pathway.IBRO neuroscience reports · 2021Review
- Specific White Matter Tracts and Diffusion Properties Predict Conversion From Mild Cognitive Impairment to Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionWhite matter hyperintensities (WMHs) increase the risk of Alzheimer's disease (AD). Whether WMHs are associated with the decline of functional neural networks in AD is debated.
methodResting-state functional magnetic resonance imaging and WMH were assessed in 78 subjects with increased amyloid levels on AV-45 positron emission tomography (PET) in different clinical stages of AD. We tested the association between WMH volume in major atlas-based fiber tract regions of interest (ROIs) and changes in functional connectivity (FC) between the tracts' projection areas within the default mode network (DMN).
resultsWMH volume within the inferior fronto-occipital fasciculus (IFOF) was the highest among all tract ROIs and associated with reduced FC in IFOF-connected DMN areas, independently of global AV-45 PET. Higher AV-45 PET contributed to reduced FC in IFOF-connected, temporal, and parietal DMN areas.
conclusionsHigh fiber tract WMH burden is associated with reduced FC in connected areas, thus adding to the effects of amyloid pathology on neuronal network function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.